WormBase Tree Display for Gene: WBGene00020788

WBGene00020788 SMap: S_parent: Sequence: T25B6
  Identity: Version: 2
    Name: CGC_name: nep-22 Person_evidence: WBPerson260
      Sequence_name: T25B6.2
      Molecular_name: T25B6.2
        T25B6.2.1
        CE14174
      Other_name: CELE_T25B6.2 Accession_evidence: NDB BX284606
      Public_name: nep-22
    DB_info: Database: AceView gene XJ655
        WormQTL gene WBGene00020788
        WormFlux gene WBGene00020788
        NDB locus_tag CELE_T25B6.2
        Panther gene CAEEL|WormBase=WBGene00020788|UniProtKB=Q22763
          family PTHR11733
        NCBI gene 181144
        RefSeq protein NM_077127.5
        TREEFAM TREEFAM_ID TF318791
        TrEMBL UniProtAcc Q22763
        UniProt_GCRP UniProtAcc Q22763
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 10 Feb 2012 15:49:10 WBPerson2970 Name_change: CGC_name: nep-22
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nep
    Allele (69)
    Strain: WBStrain00033138
      WBStrain00037406
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (31)
    Paralog (24)
    Structured_description: Concise_description: nep-22 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; NEP-22 is orthologous to Ac-mep-1, a gut luminal neprilysin which is specifically expressed in the adult life stage of Ancylostoma caninum hookworms, and whose protein product is localized to the microvilli of the gastrointestinal tract, suggesting a role in digestion. Paper_evidence: WBPaper00004584
            WBPaper00012962
            WBPaper00013276
          Curator_confirmed: WBPerson567
          Date_last_updated: 27 Mar 2014 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Located in membrane raft. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T25B6.2
    Corresponding_CDS_history: T25B6.2a:wp142
      T25B6.2b:wp142
    Corresponding_transcript: T25B6.2.1
    Other_sequence (102)
    Associated_feature: WBsf648394
      WBsf236116
      WBsf236117
      WBsf236118
  Experimental_info: RNAi_result: WBRNAi00054097 Inferred_automatically: RNAi_primary
      WBRNAi00000575 Inferred_automatically: RNAi_primary
      WBRNAi00035945 Inferred_automatically: RNAi_primary
      WBRNAi00089168 Inferred_automatically: RNAi_primary
      WBRNAi00019187 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019959
      Expr1039054
      Expr1157641
      Expr2013967
      Expr2032206
    Drives_construct: WBCnstr00024887
    Construct_product: WBCnstr00024887
    Microarray_results (19)
    Expression_cluster (260)
    Interaction (40)
  Map_info: Map: X Position: 0.573562
    Positive: Positive_clone: T25B6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00011415
    WBPaper00011735
    WBPaper00029046
    WBPaper00037777
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene