WormBase Tree Display for Gene: WBGene00020693

WBGene00020693 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: lron-8 Person_evidence: WBPerson637
      Sequence_name: T22E7.1
      Molecular_name: T22E7.1a
        T22E7.1a.1
        CE31368
        T22E7.1b
        CE33189
        T22E7.1b.1
      Other_name: CELE_T22E7.1 Accession_evidence: NDB BX284601
      Public_name: lron-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 09 Dec 2011 15:47:23 WBPerson2970 Name_change: CGC_name: lron-8
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lron
    Allele (49)
    Strain: WBStrain00047619
    RNASeq_FPKM (74)
    GO_annotation: 00083597
      00083598
      00095371
    Ortholog (49)
    Paralog: WBGene00004854 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00007261 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013542 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022129 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to be located in extracellular matrix and extracellular space. Expressed in body wall musculature; head muscle; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 64; congenital stationary night blindness 1A; and stomach cancer. Is an ortholog of several human genes including LRRN1 (leucine rich repeat neuronal 1); LRRN2 (leucine rich repeat neuronal 2); and LRRN3 (leucine rich repeat neuronal 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110870 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8082)
      DOID:1686 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:21205)
      DOID:0081225 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:21205)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20980)
      DOID:8499 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8082)
  Molecular_info: Corresponding_CDS: T22E7.1a
      T22E7.1b
    Corresponding_transcript: T22E7.1a.1
      T22E7.1b.1
    Other_sequence: FD517495.1
      CSC02279_1
    Associated_feature: WBsf643311
      WBsf983767
      WBsf217708
  Experimental_info: RNAi_result: WBRNAi00028132 Inferred_automatically: RNAi_primary
      WBRNAi00002855 Inferred_automatically: RNAi_primary
      WBRNAi00053838 Inferred_automatically: RNAi_primary
      WBRNAi00019030 Inferred_automatically: RNAi_primary
      WBRNAi00053839 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9904
      Expr1025304
      Expr1039013
      Expr1157389
      Expr2013281
      Expr2031512
    Drives_construct: WBCnstr00014390
      WBCnstr00024955
    Construct_product: WBCnstr00014390
      WBCnstr00024955
    Microarray_results (27)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Spermatogenic
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049290:rsks-1(sv31)_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059987:Wounding_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:BWM_far_posterior
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:mc2
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:pm8
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:172183_at-176110_at
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_5_5
      cgc4489_group_7
      WBPaper00005475:Aging-regulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:FedUp
      WBPaper00035560:ahr-1_downregulated
      WBPaper00036286:Pattern_C
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA300_up
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:Cluster_B
    Interaction: WBInteraction000566467
      WBInteraction000566746
  Map_info: Map: I Position: 0.445629
    Positive: Positive_clone: T22E7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene