WormBase Tree Display for Gene: WBGene00020368
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| WBGene00020368 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ast-1 | Person_evidence | WBPerson1103 | |||||
| Sequence_name | T08H4.3 | ||||||||
| Molecular_name | T08H4.3 | ||||||||
| T08H4.3.1 | |||||||||
| CE19576 | |||||||||
| Other_name | CELE_T08H4.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ast-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Jul 2005 13:34:00 | WBPerson2970 | Name_change | CGC_name | ast-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ast | ||||||||
| Allele (163) | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | ast-1 encodes one of ten C. elegans ETS-box transcription factors; AST-1 is required cell autonomously for proper initiation and maintenance of dopamine (DA) neuron fate; AST-1 acts to specify DA neuron fate by positively regulating expression of a number of DA neuron-specific genes such as dat-1 and cat-2, which encodes a dopamine transporter and tyrosine hydroxylase, respectively; AST-1 is also required for proper navigation of some interneuron axons to their targets, for differentiation of the ventral cord pioneer neuron AVG, and for pharyngeal morphogenesis; AST-1 is transiently expressed in many head neurons late in their differentiation and axon outgrowth, and in a few pharyngeal cells; AST-1 is at first nuclear, but then relocates to spots in cell bodies and even neuronal processes; hypomorphic ast-1 mutants have axons extending laterally, and crossing over from the right axon tract to the left axon bundle; null ast-1(hd92) mutants are inviable, failing to attach a working pharynx to their cuticle during development and then starving as L1 larvae; behaviorally, hypomorphic ast-1 animals are at least superficially normal, indicating that the ventral nerve cord can tolerate at least some miswiring; AST-1 also regulates odr-2 expression, while ast-1 expression is itself regulated by LIN-11. | Paper_evidence | WBPaper00026621 | |||||
| WBPaper00027206 | |||||||||
| WBPaper00032994 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 Jan 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including neuron differentiation; pharynx morphogenesis; and regulation of nematode male tail tip morphogenesis. Located in nucleus. Expressed in intestine; neurons; and rectal gland cell. Human ortholog(s) of this gene implicated in myeloid leukemia; pulmonary venoocclusive disease; and thrombocytopenia. Is an ortholog of human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3749) | ||||
| DOID:0050580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3446) | ||||||
| DOID:5453 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3446) | ||||||
| DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3446) | ||||||
| DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3749) | ||||||
| Molecular_info | Corresponding_CDS | T08H4.3 | |||||||
| Corresponding_CDS_history | T08H4.3b:wp124 | ||||||||
| Corresponding_transcript | T08H4.3.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature (20) | |||||||||
| Gene_product_binds (12) | |||||||||
| Transcription_factor | WBTranscriptionFactor000053 | ||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00007325 | ||||||||
| WBCnstr00007327 | |||||||||
| WBCnstr00007328 | |||||||||
| WBCnstr00011799 | |||||||||
| WBCnstr00011800 | |||||||||
| WBCnstr00011801 | |||||||||
| WBCnstr00012806 | |||||||||
| WBCnstr00013365 | |||||||||
| Construct_product | WBCnstr00005607 | ||||||||
| WBCnstr00007327 | |||||||||
| WBCnstr00007328 | |||||||||
| WBCnstr00009418 | |||||||||
| WBCnstr00011800 | |||||||||
| WBCnstr00011801 | |||||||||
| WBCnstr00015963 | |||||||||
| WBCnstr00017941 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (191) | |||||||||
| Interaction (67) | |||||||||
| Map_info | Map | II | Position | -5.40481 | Error | 0.087312 | |||
| Positive | Positive_clone | T08H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (29) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
