WormBase Tree Display for Gene: WBGene00019993

WBGene00019993 SMap: S_parent: Sequence: R10A10
  Identity: Version: 2
    Name: CGC_name: rbx-2
      Sequence_name: R10A10.2
      Molecular_name: R10A10.2
        R10A10.2.1
        CE12670
      Other_name: CELE_R10A10.2 Accession_evidence: NDB BX284601
      Public_name: rbx-2
    DB_info: Database: AceView gene 1G996
        WormQTL gene WBGene00019993
        WormFlux gene WBGene00019993
        NDB locus_tag CELE_R10A10.2
        Panther gene CAEEL|WormBase=WBGene00019993|UniProtKB=P91404
          family PTHR11210
        NCBI gene 172344
        RefSeq protein NM_059448.7
        TREEFAM TREEFAM_ID TF351049
        TrEMBL UniProtAcc P91404
        UniProt_GCRP UniProtAcc P91404
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 15 Nov 2004 10:37:27 WBPerson2970 Name_change: CGC_name: rbx-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rbx
    Allele (12)
    Strain: WBStrain00032118
    RNASeq_FPKM (74)
    GO_annotation: 00050896
      00050897
      00050898
      00050899
      00050900
      00050901
      00050902
      00124718
    Ortholog (31)
    Paralog: WBGene00000145 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004320 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: The R10A10.2 gene encodes an ortholog of the mammalian zinc RING finger protein SAG, which protects cells from apoptosis induced by redox agents and is a component of ubiquitin-ligase (E3) complexes; mammalian SAG binds to the yeast Cul1 protein, complements the lethality of a mutation in yeast Sag, and (when bound to yeast Cul1) has ubiquitin ligase activity and promotes poly-ubiquitination of E2/Cdc34. Paper_evidence: WBPaper00012757
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is an ortholog of human RNF7 (ring finger protein 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R10A10.2
    Corresponding_transcript: R10A10.2.1
    Other_sequence (21)
    Associated_feature: WBsf649235
      WBsf983934
      WBsf983935
      WBsf1009956
      WBsf219580
      WBsf219581
  Experimental_info: RNAi_result (20)
    Expr_pattern: Expr1015327
      Expr1038681
      Expr1155350
      Expr2015277
      Expr2033511
    Drives_construct: WBCnstr00025444
    Construct_product: WBCnstr00025444
    Microarray_results (19)
    Expression_cluster (75)
    Interaction (36)
  Map_info: Map: I Position: 1.07719 Error: 0.002046
    Positive: Positive_clone: R10A10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027315
    WBPaper00029151
    WBPaper00038491
    WBPaper00052012
    WBPaper00055090
    WBPaper00064339
    WBPaper00064898
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene