WormBase Tree Display for Gene: WBGene00019883
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| WBGene00019883 | SMap | S_parent | Sequence | R05D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | met-2 | Person_evidence | WBPerson1730 | |||||
| WBPerson268 | |||||||||
| Sequence_name | R05D3.11 | ||||||||
| Molecular_name | R05D3.11 | ||||||||
| R05D3.11.1 | |||||||||
| CE47959 | |||||||||
| Other_name | CELE_R05D3.11 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | met-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Jul 2005 13:34:00 | WBPerson2970 | Name_change | CGC_name | met-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | met | ||||||||
| Allele (77) | |||||||||
| Strain (21) | |||||||||
| Component_of_genotype | WBGenotype00000092 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Contained_in_operon | CEOP3516 | ||||||||
| Ortholog (40) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | met-2 encodes a histone methyltransferase similar to human SETDB1; during development, met-2 acts as a class B synMuv gene: loss of met-2 activity in the background of a class A or class C synMuv mutant, such as lin-15A or trr-1, respectively, results in a multivulval phenotype, indicating that met-2 acts to negatively regulate vulval cell fate specification; as met-2 is required for normal levels of histone H3K36 and H3K9 trimethylation and met-2;lin-15A animals show an increase in lin-3 EGF expression, met-2 likely acts as part of a transcriptional repressor complex that negatively regulates lin-3 EGF transcription to restrict vulval development to three of the six cells in the vulval equivalence group; in addition, genetic studies indicate that met-2 likely acts redundantly with met-1 to inhibit vulval cell fates. | Paper_evidence | WBPaper00026636 | |||||
| WBPaper00030864 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Apr 2008 00:00:00 | ||||||||
| Automated_description | Enables histone H3K36 methyltransferase activity and histone H3K9 methyltransferase activity. Involved in several processes, including negative regulation of vulval development; regulation of gene expression; and vulval cell fate commitment. Located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; neurons; and in male. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; autistic disorder; and prostate cancer. Is an ortholog of human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||||
| DOID:1909 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||||
| DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10761) | ||||||
| Molecular_info | Corresponding_CDS | R05D3.11 | |||||||
| Corresponding_CDS_history | R05D3.11:wp186 | ||||||||
| R05D3.11:wp225 | |||||||||
| R05D3.11:wp234 | |||||||||
| Corresponding_transcript | R05D3.11.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf659282 | ||||||||
| Experimental_info | RNAi_result (41) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00017003 | ||||||||
| WBCnstr00025523 | |||||||||
| WBCnstr00040148 | |||||||||
| Construct_product | WBCnstr00017003 | ||||||||
| WBCnstr00025523 | |||||||||
| WBCnstr00040148 | |||||||||
| Regulate_expr_cluster | WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1 | ||||||||
| WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1 | |||||||||
| WBPaper00060886:met-2(n4256)_downregulated | |||||||||
| WBPaper00060886:met-2(n4256)_upregulated | |||||||||
| WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated | |||||||||
| WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated | |||||||||
| WBPaper00062056:met-2(n4256)_downregulated | |||||||||
| WBPaper00062056:met-2(n4256)_upregulated | |||||||||
| Antibody | WBAntibody00002842 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (127) | |||||||||
| SAGE_tag (20) | |||||||||
| Interaction (166) | |||||||||
| Map_info | Map | III | Position | -0.275223 | Error | 0.001912 | |||
| Positive | Positive_clone | R05D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (96) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
