WormBase Tree Display for Gene: WBGene00019832
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| WBGene00019832 | SMap | S_parent | Sequence | R02F2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | osg-1 | Person_evidence | WBPerson3192 | |||||
| Sequence_name | R02F2.2 | ||||||||
| Molecular_name | R02F2.2 | ||||||||
| R02F2.2.1 | |||||||||
| CE39517 | |||||||||
| Other_name | CELE_R02F2.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | osg-1 | ||||||||
| DB_info | Database | AceView | gene | 3G587 | |||||
| WormQTL | gene | WBGene00019832 | |||||||
| WormFlux | gene | WBGene00019832 | |||||||
| NDB | locus_tag | CELE_R02F2.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00019832|UniProtKB=Q21653 | |||||||
| family | PTHR12877 | ||||||||
| NCBI | gene | 175756 | |||||||
| RefSeq | protein | NM_065771.7 | |||||||
| SwissProt | UniProtAcc | Q21653 | |||||||
| TREEFAM | TREEFAM_ID | TF317017 | |||||||
| UniProt_GCRP | UniProtAcc | Q21653 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 09 Jan 2015 16:33:20 | WBPerson2970 | Name_change | CGC_name | osg-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | osg | ||||||||
| Allele (160) | |||||||||
| Strain | WBStrain00032256 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00072344 | ||||||||
| 00072345 | |||||||||
| 00072346 | |||||||||
| 00124595 | |||||||||
| Ortholog (54) | |||||||||
| Structured_description | Concise_description | R02F2.2 encodes a guanine nucleotide exchange factor of the Dbl family; R02F2.2 plays a role in aging, and appears to be recruited, under conditions of oxidative stress, to effect loss of neuronal function via dysregulation of RHO-1 GTPase-mediated signaling and subsequent effects on the actin cytoskeleton and actin dynamics; an R02F2.2::GFP reporter fusion is expressed in body wall muscles, head muscles, and in several neurons in the head, including the ASE and FLP neurons. | Paper_evidence | WBPaper00046168 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Dec 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Involved in response to oxidative stress. Expressed in body wall musculature and head neurons. Is an ortholog of human ARHGEF17 (Rho guanine nucleotide exchange factor 17). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R02F2.2 | |||||||
| Corresponding_CDS_history | R02F2.2:wp152 | ||||||||
| Corresponding_transcript | R02F2.2.1 | ||||||||
| Other_sequence | JI227717.1 | ||||||||
| Oden_isotig22983 | |||||||||
| JI215742.1 | |||||||||
| Name_isotig07645 | |||||||||
| NAC01448_1 | |||||||||
| BU086801.1 | |||||||||
| Associated_feature | WBsf645172 | ||||||||
| WBsf992406 | |||||||||
| WBsf992407 | |||||||||
| WBsf992408 | |||||||||
| WBsf1014892 | |||||||||
| WBsf1014893 | |||||||||
| WBsf1014894 | |||||||||
| WBsf224935 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr8758 | ||||||||
| Expr12108 | |||||||||
| Expr1024754 | |||||||||
| Expr1038597 | |||||||||
| Expr1154862 | |||||||||
| Expr2014638 | |||||||||
| Expr2032871 | |||||||||
| Drives_construct | WBCnstr00005768 | ||||||||
| WBCnstr00020214 | |||||||||
| WBCnstr00025562 | |||||||||
| Construct_product | WBCnstr00025562 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (172) | |||||||||
| Interaction | WBInteraction000185628 | ||||||||
| WBInteraction000321442 | |||||||||
| WBInteraction000371190 | |||||||||
| WBInteraction000426809 | |||||||||
| Map_info | Map | III | Position | -1.61478 | |||||
| Positive | Positive_clone | R02F2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00035488 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00046168 | |||||||||
| WBPaper00053008 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
