WormBase Tree Display for Gene: WBGene00019565

WBGene00019565 SMap: S_parent: Sequence: K09D9
  Identity: Version: 2
    Name: CGC_name: cyp-35A3
      Sequence_name: K09D9.2
      Molecular_name: K09D9.2
        K09D9.2.1
        CE21056
      Other_name: CELE_K09D9.2 Accession_evidence: NDB BX284605
      Public_name: cyp-35A3
    DB_info: Database: AceView gene 5E497
        WormQTL gene WBGene00019565
        WormFlux gene WBGene00019565
        NDB locus_tag CELE_K09D9.2
        Panther gene CAEEL|WormBase=WBGene00019565|UniProtKB=Q9N5I1
          family PTHR24300
        NCBI gene 187209
        RefSeq protein NM_071720.6
        TrEMBL UniProtAcc Q9N5I1
        UniProt_GCRP UniProtAcc Q9N5I1
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-35A3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (50)
    Strain: WBStrain00032730
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (172)
    Paralog (44)
    Structured_description: Concise_description: cyp-35A3 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; in addition, cyp-35A(RNAi) also results in a reduction of fat content; cyp-35A3 reporter gene fusions are strongly expressed in the intestine following treatment with xenobiotics. Paper_evidence: WBPaper00005655
            WBPaper00025207
            WBPaper00029387
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (42)
  Molecular_info: Corresponding_CDS: K09D9.2
    Corresponding_transcript: K09D9.2.1
    Other_sequence: EY459839.1
    Associated_feature: WBsf646734
      WBsf978993
      WBsf231624
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr4664
      Expr1038451
      Expr1154117
      Expr2010736
      Expr2028973
    Drives_construct: WBCnstr00012158
      WBCnstr00025764
    Construct_product: WBCnstr00025764
    Microarray_results (15)
    Expression_cluster (296)
    Interaction (28)
  Map_info: Map: V Position: -7.01998 Error: 0.006429
    Positive: Positive_clone: K09D9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene