WormBase Tree Display for Gene: WBGene00019227

WBGene00019227 SMap: S_parent: Sequence: H22K11
  Identity: Version: 2
    Name: CGC_name: sgca-1 Person_evidence: WBPerson1263
            WBPerson2876
      Sequence_name: H22K11.4
      Molecular_name: H22K11.4a
        H22K11.4a.1
        CE37119
        H22K11.4b
        CE40082
        H22K11.4b.1
      Other_name: CELE_H22K11.4 Accession_evidence: NDB BX284606
      Public_name: sgca-1
    DB_info: Database: WormQTL gene WBGene00019227
        WormFlux gene WBGene00019227
        NDB locus_tag CELE_H22K11.4
        Panther gene CAEEL|WormBase=WBGene00019227|UniProtKB=H2L0C3
          family PTHR10132
        NCBI gene 180946
        RefSeq protein NM_001373339.3
            NM_001373338.3
        TREEFAM TREEFAM_ID TF314655
        TrEMBL UniProtAcc Q1XFY3
            H2L0C3
        UniProt_GCRP UniProtAcc H2L0C3
        OMIM gene 600119
            604149
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Oct 2007 11:43:25 WBPerson2970 Name_change: CGC_name: sgca-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sgca
    Allele (40)
    Strain: WBStrain00032061
    RNASeq_FPKM (74)
    GO_annotation: 00022985
      00022986
      00022987
      00124123
      00124124
      00124125
    Ortholog: WBGene00051437 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00032144 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00160774 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00224931 Brugia malayi From_analysis: WormBase-Compara
      CSP26.g12497 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g14287 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP31.g20734 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP40.g18774 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-sgca-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp5_scaffold_00033.g1830 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00294 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024643 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g23802 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0194100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19300 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00240618 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266055 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285580 Trichuris muris From_analysis: WormBase-Compara
      RGD:1308062 Rattus norvegicus From_analysis: OrthoFinder
            EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0032013 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-030724-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-041111-121 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      HGNC:10805 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:10808 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      MGI:894698 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      MGI:1329042 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1303201 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
    Structured_description: Concise_description: sgca-1 encodes a protein orthologous to the human gene SARCOGLYCAN, ALPHA (50KD DYSTROPHIN-ASSOCIATED GLYCOPROTEIN) (SGCA; OMIM:600119), which when mutated leads to disease. Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 19 Dec 2009 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Located in striated muscle dense body. Expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D; myoclonic dystonia 11; and stomach cancer. Is an ortholog of human SGCA (sarcoglycan alpha) and SGCE (sarcoglycan epsilon). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110278 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10805)
      DOID:9884 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10805)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10808)
      DOID:0090034 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10808)
  Molecular_info: Corresponding_CDS: H22K11.4a
      H22K11.4b
    Corresponding_CDS_history: H22K11.4:wp121
      H22K11.4:wp128
      H22K11.4:wp156
      H22K11.4a:wp271
      H22K11.4b:wp271
    Corresponding_transcript: H22K11.4a.1
      H22K11.4b.1
    Other_sequence: Oden_isotig26597
      JI171235.1
      DVC02223_1
      CSC02338_1
      Acan_isotig17435
      Dviv_isotig28156
      FD514430.1
      EV852337.1
    Associated_feature: WBsf654088
      WBsf654089
      WBsf670663
  Experimental_info: RNAi_result: WBRNAi00049458 Inferred_automatically: RNAi_primary
      WBRNAi00016297 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4924
      Expr1015295
      Expr1038304
      Expr1153186
      Expr2015800
      Expr2034033
    Drives_construct: WBCnstr00006007
      WBCnstr00012337
      WBCnstr00025982
    Construct_product: WBCnstr00006007
      WBCnstr00008298
      WBCnstr00018329
      WBCnstr00025982
    Antibody: WBAntibody00002076
    Microarray_results (24)
    Expression_cluster (123)
    Interaction: WBInteraction000460218
  Map_info: Map: X Position: -2.43167 Error: 0.004636
    Positive: Positive_clone: H22K11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005519
    WBPaper00031003
    WBPaper00035538
    WBPaper00038491
    WBPaper00039233
    WBPaper00041089
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene