WormBase Tree Display for Gene: WBGene00019127
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| WBGene00019127 | SMap | S_parent | Sequence | F59G1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cgt-3 | Person_evidence | WBPerson365 | |||||
| Sequence_name | F59G1.1 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CELE_F59G1.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cgt-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 17 Mar 2006 15:11:54 | WBPerson2970 | Name_change | CGC_name | cgt-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cgt | ||||||||
| Allele (90) | |||||||||
| Strain | WBStrain00037183 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP2232 | ||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00011517 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00011519 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00017625 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cgt-3 encodes a transmembrane protein that is one of three C. elegans ceramide glucosyltransferases; by homology, CGT-3 is predicted to localize to the Golgi membrane and catalyze the transfer of glucose from UDP-glucose to ceramide to synthesize glucosylceramide, a glycosphingolipid precursor; although cgt-3 mutant worms show no obvious defects, animals doubly mutant for cgt-3 and cgt-1 arrest development in the early L1 larval stage, showing impaired feeding ability; in addition, cgt-3;cgt-1 and cgt-3;cgt-1;cgt-2 mutant animals show reduced glucosylceramide levels; a CGT-3::GFP reporter fusion is expressed in pharyngeal tissues, the intestine, the pharyngeal-intestinal and intestinal-rectal valves, the rectal gland cells, head mesodermal cells and additional unidentified head cells; cgt-3 expression in mouse GM95 cells, deficient in glucosylceramide due to a defect in glucosylceramide synthase, confirms that CGT-3 has ceramide glucosyltransferase activity. | Paper_evidence | WBPaper00032934 | |||||
| WBPaper00035299 | |||||||||
| WBPaper00035300 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Oct 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable ceramide glucosyltransferase activity. Involved in several processes, including glucosylceramide biosynthetic process; regulation of mesodermal cell fate specification; and regulation of protein localization to basolateral plasma membrane. Located in plasma membrane. Expressed in several structures, including germ line; pharyngeal muscle cell; pharyngeal-intestinal valve; rectal gland cell; and rectal valve cell. Is an ortholog of human UGCG (UDP-glucose ceramide glucosyltransferase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F59G1.1a | |||||||
| F59G1.1b | |||||||||
| F59G1.1d | |||||||||
| Corresponding_CDS_history | F59G1.1c:wp261 | ||||||||
| Corresponding_transcript | F59G1.1c | ||||||||
| F59G1.1a.1 | |||||||||
| F59G1.1b.1 | |||||||||
| F59G1.1b.2 | |||||||||
| F59G1.1d.1 | |||||||||
| Other_sequence | Dviv_isotig16419 | ||||||||
| CR01538 | |||||||||
| CBC08690_1 | |||||||||
| CRC04587_1 | |||||||||
| CBC03012_1 | |||||||||
| Dviv_isotig16418 | |||||||||
| PPC16435_1 | |||||||||
| Associated_feature | WBsf644243 | ||||||||
| WBsf657640 | |||||||||
| WBsf657641 | |||||||||
| WBsf657642 | |||||||||
| WBsf657643 | |||||||||
| WBsf987995 | |||||||||
| WBsf221361 | |||||||||
| WBsf221362 | |||||||||
| WBsf221363 | |||||||||
| WBsf221364 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Chronogram1781 | ||||||||
| Expr6269 | |||||||||
| Expr8290 | |||||||||
| Expr8572 | |||||||||
| Expr11539 | |||||||||
| Expr1013875 | |||||||||
| Expr1038257 | |||||||||
| Expr1152973 | |||||||||
| Expr2009948 | |||||||||
| Expr2028188 | |||||||||
| Drives_construct | WBCnstr00003401 | ||||||||
| WBCnstr00013239 | |||||||||
| WBCnstr00013370 | |||||||||
| WBCnstr00019065 | |||||||||
| Construct_product | WBCnstr00013239 | ||||||||
| WBCnstr00019065 | |||||||||
| Microarray_results (46) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction (17) | |||||||||
| WBProcess | WBbiopr:00000137 | ||||||||
| Map_info | Map | II | Position | -0.853217 | Error | 0.000266 | |||
| Positive | Positive_clone | F59G1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
