WormBase Tree Display for Gene: WBGene00018853
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| WBGene00018853 | SMap | S_parent | Sequence | F55A4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sec-22 | Person_evidence | WBPerson3132 | |||||
| Sequence_name | F55A4.1 | ||||||||
| Molecular_name | F55A4.1 | ||||||||
| F55A4.1.1 | |||||||||
| CE19895 | |||||||||
| Other_name | CELE_F55A4.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sec-22 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 26 Mar 2010 11:10:22 | WBPerson2970 | Name_change | CGC_name | sec-22 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sec | ||||||||
| Allele (23) | |||||||||
| Strain | WBStrain00001453 | ||||||||
| WBStrain00002575 | |||||||||
| WBStrain00032937 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00004897 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00004898 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004899 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007200 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00014084 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015164 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022077 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00044062 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Automated_description | Predicted to enable SNAP receptor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and organelle membrane. Predicted to be part of SNARE complex. Expressed in somatic cell and tail. Used to study Parkinson's disease. Is an ortholog of human SEC22B (SEC22 homolog B, vesicle trafficking protein). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00031384 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jul 2013 00:00:00 | ||||||||
| Disease_relevance | In an elegans model of Parkinson''s disease, where human alpha-synuclein was overexpressed, RNA interference studies showed that the elegans sec-22/SEC22A (homolog of yeast sec22p vesicle trafficking protein), significantly protected against age- and dose-dependent degeneration in the dopamine neurons of transgenic worms; such models allow the identification of human modifier proteins of alpha-synuclein dependent misfolding and neurodegeneration, these proteins may also be new potential targets for therapeutic intervention. | Homo sapiens | Paper_evidence | WBPaper00031384 | |||||
| Accession_evidence | OMIM | 612442 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jul 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000216 | ||||||||
| Molecular_info | Corresponding_CDS | F55A4.1 | |||||||
| Corresponding_transcript | F55A4.1.1 | ||||||||
| Other_sequence (41) | |||||||||
| Associated_feature | WBsf647814 | ||||||||
| WBsf235303 | |||||||||
| WBsf235304 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00076480 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00110503 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032843 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015681 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048433 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110527 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110515 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1322 | ||||||||
| Chronogram1425 | |||||||||
| Expr6194 | |||||||||
| Expr13362 | |||||||||
| Expr1022198 | |||||||||
| Expr1038135 | |||||||||
| Expr1152220 | |||||||||
| Expr2015712 | |||||||||
| Expr2033944 | |||||||||
| Drives_construct | WBCnstr00004232 | ||||||||
| WBCnstr00004233 | |||||||||
| WBCnstr00026240 | |||||||||
| WBCnstr00039343 | |||||||||
| Construct_product | WBCnstr00006220 | ||||||||
| WBCnstr00006227 | |||||||||
| WBCnstr00026240 | |||||||||
| WBCnstr00039343 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (51) | |||||||||
| Map_info | Map | X | Position | -18.7988 | Error | 0.009491 | |||
| Positive | Positive_clone | F55A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031384 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042644 | |||||||||
| WBPaper00043668 | |||||||||
| WBPaper00050534 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061547 | |||||||||
| WBPaper00066137 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
