WormBase Tree Display for Gene: WBGene00018734

WBGene00018734 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 2
    Name: Sequence_name: F53A10.2
      Molecular_name (22)
      Other_name: CELE_F53A10.2 Accession_evidence: NDB BX284602
      Public_name: F53A10.2
    DB_info: Database: AceView gene 2B519
        WormQTL gene WBGene00018734
        WormFlux gene WBGene00018734
        NDB locus_tag CELE_F53A10.2
        Panther gene CAEEL|WormBase=WBGene00018734|UniProtKB=H2L055
          family PTHR15711
        NCBI gene 173502
        RefSeq protein NM_001322703.3
            NM_001322701.3
            NM_001393000.1
            NM_001393001.1
            NM_001322702.3
            NM_001027019.3
        TrEMBL UniProtAcc A0A131MBF2
            H2L055
            A0A131MCP2
            A0A131MBM3
            Q8IA84
            Q965M4
        UniProt_GCRP UniProtAcc H2L055
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Nov 2004 17:10:33 WBPerson2970 Event: Acquires_merge: WBGene00018733
      Acquires_merge: WBGene00018733
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (847)
    Strain: WBStrain00055198
    RNASeq_FPKM (74)
    GO_annotation: 00001998
      00001999
      00002000
      00022854
      00022855
      00123774
      00123775
      00123776
    Ortholog (41)
    Paralog: WBGene00012100 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: F53A10.2 encodes a Rap1GAP homolog; a region of F53A10.2 encompassing one GoLoco motif specifically binds GOA-1 in yeast two-hybrid assays, and also binds itself; F53A10.2 is expressed in hypodermal seam cells, various neurons, and intestinal cells; F53A10.2 has no obvious function or phenotype in RNAi assays, whether in a normal background or in goa-1(-) or goa-1(gf) mutant backgrounds. Paper_evidence: WBPaper00006194
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytoplasm. Expressed in intestine; neurons; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; endocrine gland cancer (multiple); and myelodysplastic syndrome. Is an ortholog of human RAP1GAP (RAP1 GTPase activating protein) and RAP1GAP2 (RAP1 GTPase activating protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3969 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:3312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:0050908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:1909 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:1312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
  Molecular_info: Corresponding_CDS: F53A10.2a
      F53A10.2b
      F53A10.2c
      F53A10.2d
      F53A10.2e
      F53A10.2f
    Corresponding_transcript: F53A10.2a.1
      F53A10.2b.1
      F53A10.2b.2
      F53A10.2b.3
      F53A10.2b.4
      F53A10.2b.5
      F53A10.2c.1
      F53A10.2d.1
      F53A10.2e.1
      F53A10.2f.1
    Other_sequence (48)
    Associated_feature (40)
  Experimental_info: RNAi_result: WBRNAi00032647 Inferred_automatically: RNAi_primary
      WBRNAi00063378 Inferred_automatically: RNAi_primary
      WBRNAi00015207 Inferred_automatically: RNAi_primary
      WBRNAi00063366 Inferred_automatically: RNAi_primary
      WBRNAi00020851 Inferred_automatically: RNAi_primary
      WBRNAi00032648 Inferred_automatically: RNAi_primary
      WBRNAi00048037 Inferred_automatically: RNAi_primary
      WBRNAi00015447 Inferred_automatically: RNAi_primary
      WBRNAi00048036 Inferred_automatically: RNAi_primary
      WBRNAi00048038 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2756
      Expr1015564
      Expr1038064
      Expr1151853
      Expr2004017
      Expr2022239
    Drives_construct: WBCnstr00010936
    Construct_product: WBCnstr00010936
    Microarray_results (40)
    Expression_cluster (105)
    Interaction (40)
  Map_info: Positive: Positive_clone: F53A10 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: II -15.5618
  Reference: WBPaper00036647
    WBPaper00038491
    WBPaper00055090
  Method: Gene