WormBase Tree Display for Gene: WBGene00018572
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| WBGene00018572 | SMap | S_parent | Sequence | F47F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-42 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F47F6.1 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | Cel-Mir-10-P3e | Remark | MirGeneDB 2.1 import | ||||||
| CELE_F47F6.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | lin-42 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 28 Oct 2004 11:37:51 | WBPerson1867 | Event | Acquires_merge | WBGene00003027 | ||||
| Acquires_merge | WBGene00003027 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Allele (513) | |||||||||
| Legacy_information | See also n1089 | ||||||||
| [C.elegansII] n1089 : precocious HSN differentiation; heterochronicdefect in L4/A switch. [MT; VT] | |||||||||
| [Rougvie AE] Null alleles cause precocious terminal differentiation of lateral hypodermal seam cells (V cells) during the L3 molt. | |||||||||
| Strain | WBStrain00026956 | ||||||||
| WBStrain00032533 | |||||||||
| WBStrain00007649 | |||||||||
| WBStrain00007650 | |||||||||
| WBStrain00055474 | |||||||||
| In_cluster | MIR-10 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | lin-42 encodes three PAS domain-containing proteins orthologous to insect and vertebrate Period proteins that function in regulation of circadian rhythms; during larval development, lin-42 functions in the heterochronic pathway to regulate developmental switches that occurs in multiple tissues, including the hypodermis, gonad, sex myoblasts, and vulva; genetic analysis suggests that, in the hypodermis, lin-42 acts downstream of lin-46 and in the hypodermis and gonad, in parallel to daf-12 and upstream of lin-29; lin-42 mRNA levels oscillate during larval development with peak levels seen during intermolts and low levels seen during ecdysis and after the L4-to-adult molt; LIN-42 protein appears to be a widely expressed nuclear protein whose levels also fluctuate during larval stages, with peak protein typically seen towards the latter half of each larval stage in a cell type-specific manner, and then disappearing during each successive molt; in addition to three PAS domain-containing proteins, lin-42 also encodes a protein that lacks the PAS domain; transformation rescue experiments indicate that the LIN-42 isoform lacking the PAS domain is sufficient for rescue when present in multiple copies. | Paper_evidence | WBPaper00003729 | |||||
| WBPaper00013416 | |||||||||
| WBPaper00028283 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Oct 2009 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of dauer larval development; negative regulation of miRNA transcription; and regulation of development, heterochronic. Located in cytoplasm and nucleus. Expressed in head; hyp7 syncytium; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 1. Is an ortholog of human PER1 (period circadian regulator 1) and PER2 (period circadian regulator 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050628 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8846) | ||||
| DOID:0110011 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8846) | ||||||
| Molecular_info | Corresponding_CDS | F47F6.1a | |||||||
| F47F6.1b | |||||||||
| F47F6.1c | |||||||||
| F47F6.1d | |||||||||
| F47F6.1e | |||||||||
| F47F6.1f | |||||||||
| F47F6.1g | |||||||||
| Corresponding_CDS_history | F47F6.1:wp129 | ||||||||
| Corresponding_transcript | F47F6.1a.1 | ||||||||
| F47F6.1b.1 | |||||||||
| F47F6.1c.1 | |||||||||
| F47F6.1d.1 | |||||||||
| F47F6.1e.1 | |||||||||
| F47F6.1f.1 | |||||||||
| F47F6.1g.1 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature (30) | |||||||||
| Experimental_info | RNAi_result (89) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00003256 | ||||||||
| WBCnstr00004854 | |||||||||
| WBCnstr00009446 | |||||||||
| WBCnstr00009449 | |||||||||
| WBCnstr00009450 | |||||||||
| WBCnstr00014371 | |||||||||
| WBCnstr00020646 | |||||||||
| WBCnstr00020647 | |||||||||
| Construct_product | WBCnstr00018303 | ||||||||
| Antibody | WBAntibody00001126 | ||||||||
| WBAntibody00002530 | |||||||||
| WBAntibody00002829 | |||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (237) | |||||||||
| Interaction (120) | |||||||||
| WBProcess | WBbiopr:00000083 | ||||||||
| Map_info | Map | II | Position | -15.5598 | |||||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf3 | |||||||
| Positive_clone | F20E9 | ||||||||
| F47F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 4219 | |||||||
| Multi_point | 1469 | ||||||||
| 1672 | |||||||||
| 3907 | |||||||||
| 4672 | |||||||||
| 5516 | |||||||||
| Pos_neg_data | 4727 | ||||||||
| 4728 | |||||||||
| 4729 | |||||||||
| Landmark_gene | |||||||||
| Reference (129) | |||||||||
| Method | Gene |
