WormBase Tree Display for Gene: WBGene00018340

WBGene00018340 SMap: S_parent: Sequence: F42A10
  Identity: Version: 2
    Name: CGC_name: anmt-2 Person_evidence: WBPerson260
      Sequence_name: F42A10.3
      Molecular_name: F42A10.3
        F42A10.3.1
        CE29316
      Other_name: CELE_F42A10.3 Accession_evidence: NDB BX284603
      Public_name: anmt-2
    DB_info: Database: AceView gene 3H244
        WormQTL gene WBGene00018340
        WormFlux gene WBGene00018340
        NDB locus_tag CELE_F42A10.3
        Panther gene CAEEL|WormBase=WBGene00018340|UniProtKB=Q20308
          family PTHR10867
        NCBI gene 175868
        RefSeq protein NM_065933.10
        TREEFAM TREEFAM_ID TF313114
        TrEMBL UniProtAcc Q20308
        UniProt_GCRP UniProtAcc Q20308
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 04 Sep 2012 12:07:47 WBPerson2970 Name_change: CGC_name: anmt-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: anmt
    Allele (55)
    Strain: WBStrain00037687
    RNASeq_FPKM (74)
    GO_annotation: 00067773
      00067774
      00067775
      00123488
    Ortholog (33)
    Paralog: WBGene00011573 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015124 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable N-methyltransferase activity. Predicted to be located in cytosol. Expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; multiple sclerosis; and renal cell carcinoma. Is an ortholog of human INMT (indolethylamine N-methyltransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9160)
      DOID:7693 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7861)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7861)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9160)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7861)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9160)
  Molecular_info: Corresponding_CDS: F42A10.3
    Corresponding_transcript: F42A10.3.1
    Other_sequence (34)
    Associated_feature: WBsf666970
      WBsf666971
      WBsf992660
      WBsf992661
      WBsf992662
      WBsf1015040
      WBsf1015041
      WBsf226771
  Experimental_info: RNAi_result: WBRNAi00032117 Inferred_automatically: RNAi_primary
      WBRNAi00005464 Inferred_automatically: RNAi_primary
      WBRNAi00014791 Inferred_automatically: RNAi_primary
      WBRNAi00047056 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr92
      Expr431
      Expr1012884
      Expr1037896
      Expr1150919
      Expr2009339
      Expr2027575
    Drives_construct: WBCnstr00026599
    Construct_product: WBCnstr00026599
    Microarray_results (18)
    Expression_cluster: WBPaper00033065:isp-1-1(qm150)_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037682:sma-2_downregulated
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038168:lin-35_downregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045861:ash-2(tm1095)_upregulated
      WBPaper00045861:set-2(ok952)_upregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049954:BPA_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_specific
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:pharynx_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059194:klf-1(RNAi)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059895:wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060273:isp-1(qm150)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:hmc
      WBPaper00061340:hmc_homolog
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:mu_sph
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:F42A10.3-clec-227
      WBPaper00061651:hmc_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064502:spe-44(fx110)_downregulated
      WBPaper00064565:dyf-1(mn335)_regulated_protein
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:4_2
      WBPaper00065841:7_0
      WBPaper00065841:7_3
      WBPaper00065841:7_4
      WBPaper00065841:24_0
      WBPaper00065841:26_1
      WBPaper00065841:26_2
      WBPaper00065841:38_0
      WBPaper00065841:38_1
      WBPaper00065841:38_2
      WBPaper00065841:38_3
      WBPaper00065841:143_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_downregulated
      cgc4386_cluster_3_4
      cgc4489_group_24
      cgc4489_male_enriched_neuronal_genes
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:FedUp
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037113:Diazinon_16C_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc6390]:Cluster_C
      [cgc6390]:male_sex-enriched
    Interaction (16)
  Map_info: Map: III Position: -1.41271
    Positive: Positive_clone: F42A10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene