WormBase Tree Display for Gene: WBGene00018334
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| WBGene00018334 | SMap | S_parent | Sequence | F42A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyp-33E2 | |||||||
| Sequence_name | F42A9.5 | ||||||||
| Molecular_name | F42A9.5 | ||||||||
| F42A9.5.1 | |||||||||
| CE41900 | |||||||||
| F42A9.5.2 | |||||||||
| F42A9.5.3 | |||||||||
| Other_name | CELE_F42A9.5 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | cyp-33E2 | ||||||||
| DB_info | Database | AceView | gene | 4J373 | |||||
| WormQTL | gene | WBGene00018334 | |||||||
| WormFlux | gene | WBGene00018334 | |||||||
| NDB | locus_tag | CELE_F42A9.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018334|UniProtKB=Q27499 | |||||||
| family | PTHR24300 | ||||||||
| NCBI | gene | 185653 | |||||||
| RefSeq | protein | NM_069069.5 | |||||||
| TrEMBL | UniProtAcc | Q27499 | |||||||
| UniProt_GCRP | UniProtAcc | Q27499 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-33E2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (33) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (72) | |||||||||
| Paralog (44) | |||||||||
| Structured_description | Concise_description | cyp-33E2 encodes a cytochrome P450; when co-expressed with human CPR in vitro, CYP-33E2 exhibits monooxygenase activity on a variety of long-chain fatty acid substrates, including eicosapentaenoic acid and arachidonic acid; cyp-33E2(RNAi) animals show reduced rates of pharyngeal pumping, suggesting that CYP-33E2-generated metabolites may play a role in regulating pharyngeal muscle contraction; a cyp-33E2::GFP reporter fusion is expressed in the pharynx, particularly in the pharyngeal marginal cells, throughout larval development and adulthood. | Paper_evidence | WBPaper00038127 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Feb 2011 00:00:00 | ||||||||
| Automated_description | Enables monooxygenase activity. Involved in long-chain fatty acid metabolic process and regulation of pharyngeal pumping. Located in intracellular membrane-bounded organelle. Expressed in pharynx. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Is an ortholog of human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2622) | ||||
| DOID:1073 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2622) | ||||||
| Molecular_info | Corresponding_CDS | F42A9.5 | |||||||
| Corresponding_CDS_history | F42A9.5:wp185 | ||||||||
| Corresponding_transcript | F42A9.5.1 | ||||||||
| F42A9.5.2 | |||||||||
| F42A9.5.3 | |||||||||
| Other_sequence | GR12232 | ||||||||
| OOC00987_1 | |||||||||
| FC540690.1 | |||||||||
| Oden_isotig25521 | |||||||||
| BUC01742_1 | |||||||||
| BXC03257_1 | |||||||||
| GRC01039_1 | |||||||||
| CJC14474_1 | |||||||||
| BXC02717_1 | |||||||||
| ACC26323_1 | |||||||||
| Associated_feature | WBsf646176 | ||||||||
| WBsf646177 | |||||||||
| WBsf997249 | |||||||||
| WBsf1017862 | |||||||||
| WBsf1017863 | |||||||||
| WBsf228714 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00078662 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00078574 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110282 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014810 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032128 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110653 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047078 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092669 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11526 | ||||||||
| Expr1019180 | |||||||||
| Expr1150943 | |||||||||
| Expr2010724 | |||||||||
| Expr2028962 | |||||||||
| Drives_construct | WBCnstr00019058 | ||||||||
| WBCnstr00026605 | |||||||||
| Construct_product | WBCnstr00026605 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (35) | |||||||||
| Map_info | Map | IV | Position | 3.90891 | Error | 0.001424 | |||
| Positive | Positive_clone | F42A9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
