WormBase Tree Display for Gene: WBGene00017763

WBGene00017763 SMap: S_parent: Sequence: F23H11
  Identity: Version: 2
    Name: CGC_name: crls-1 Person_evidence: WBPerson8897
      Sequence_name: F23H11.9
      Molecular_name: F23H11.9a
        F23H11.9a.1
        CE09617
        F23H11.9b
        CE37763
        F23H11.9b.1
      Other_name: CELE_F23H11.9 Accession_evidence: NDB BX284603
      Public_name: crls-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 26 Feb 2009 11:04:20 WBPerson9133 Name_change: CGC_name: crls-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: crls
    Allele (45)
    RNASeq_FPKM (74)
    GO_annotation (23)
    Contained_in_operon: CEOP3048
    Ortholog: WBGene00035496 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00064887 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00102144 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00143836 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00123803 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00223813 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g4335 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g15571 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g6548 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g18658 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g22493 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g21099 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12072 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8137 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g2674 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g11871 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00039.g2152 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-crls-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g16704 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01016.g17604 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_16030 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_23770 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_011850 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05372 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g20712 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30334000 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g6845 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243677 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00256939 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000002301 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0039360 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2519 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:16148 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1913836 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1311037 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00019255 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: crls-1 encodes a cardiolipin synthase; by homology, CRLS-1 is predicted to catalyze cardiolipin biosynthesis from phosphatidylglycerol and cytidinediphosphate-diacylglycerol, and loss of crls-1 activity results in reduced levels of cardiolipin and elevated levels of phosphatidylglycerol; in C. elegans, crls-1 activity is required for normal germ cell mitochondrial membrane potential and cristae morphology, as well as for germ cell proliferation. Paper_evidence: WBPaper00040537
          Curator_confirmed: WBPerson1843
          Date_last_updated: 21 Dec 2011 00:00:00
      Automated_description: Enables cardiolipin synthase activity. Involved in cardiolipin biosynthetic process; regulation of cell population proliferation; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Is an ortholog of human CRLS1 (cardiolipin synthase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070430 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16148)
  Molecular_info: Corresponding_CDS: F23H11.9a
      F23H11.9b
    Corresponding_CDS_history: F23H11.9:wp135
    Corresponding_transcript: F23H11.9a.1
      F23H11.9b.1
    Other_sequence (35)
    Associated_feature: WBsf666549
      WBsf666550
      WBsf666551
      WBsf991186
      WBsf226155
  Experimental_info: RNAi_result: WBRNAi00013835 Inferred_automatically: RNAi_primary
      WBRNAi00111229 Inferred_automatically: RNAi_primary
      WBRNAi00023724 Inferred_automatically: RNAi_primary
      WBRNAi00023212 Inferred_automatically: RNAi_primary
      WBRNAi00045448 Inferred_automatically: RNAi_primary
      WBRNAi00006523 Inferred_automatically: RNAi_primary
      WBRNAi00023437 Inferred_automatically: RNAi_primary
      WBRNAi00024011 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1024443
      Expr1037628
      Expr1149367
      Expr2010533
      Expr2028773
    Drives_construct: WBCnstr00027039
    Construct_product: WBCnstr00027039
    Microarray_results (22)
    Expression_cluster (54)
    Interaction (69)
  Map_info: Map: III Position: -25.3228 Error: 0.030952
    Positive: Positive_clone: F23H11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00034409
    WBPaper00036608
    WBPaper00036609
    WBPaper00038491
    WBPaper00039610
    WBPaper00040537
    WBPaper00042257
    WBPaper00050263
    WBPaper00055090
    WBPaper00056678
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene