WormBase Tree Display for Gene: WBGene00017699
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| WBGene00017699 | SMap | S_parent | Sequence | F22D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | flcn-1 | Person_evidence | WBPerson15935 | |||||
| Sequence_name | F22D3.2 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | CELE_F22D3.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | flcn-1 | ||||||||
| DB_info | Database | AceView | gene | 2H237 | |||||
| WormQTL | gene | WBGene00017699 | |||||||
| WormFlux | gene | WBGene00017699 | |||||||
| OMIM | disease | 135150 | |||||||
| gene | 607273 | ||||||||
| NDB | locus_tag | CELE_F22D3.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00017699|UniProtKB=H2KY80 | |||||||
| family | PTHR31441 | ||||||||
| NCBI | gene | 174134 | |||||||
| RefSeq | protein | NM_001306549.4 | |||||||
| NM_001330952.3 | |||||||||
| NM_001276732.2 | |||||||||
| NM_001381469.1 | |||||||||
| NM_001306551.3 | |||||||||
| NM_001381470.1 | |||||||||
| NM_001026937.5 | |||||||||
| TrEMBL | UniProtAcc | S6FCY3 | |||||||
| S6EZM3 | |||||||||
| K0M7B5 | |||||||||
| J7S130 | |||||||||
| S6F533 | |||||||||
| Q5DX40 | |||||||||
| S6FMZ4 | |||||||||
| UniProt_GCRP | UniProtAcc | S6FMZ4 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 29 Jun 2012 17:03:10 | WBPerson2970 | Name_change | CGC_name | flcn-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | flcn | ||||||||
| Allele (252) | |||||||||
| Strain | WBStrain00031743 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | F22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated inBirt-Hogg-Dube syndrome). | Paper_evidence | WBPaper00028837 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 11 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Expressed in excretory cell; nervous system; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in several diseases, including Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Is an ortholog of human FLCN (folliculin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050676 | Homo sapiens | Paper_evidence | WBPaper00048631 | ||||
| Accession_evidence | OMIM | 135150 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Nov 2015 00:00:00 | ||||||||
| Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | |||||
| DOID:0080218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||||
| DOID:0050676 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||||
| Models_disease_in_annotation | WBDOannot00000382 | ||||||||
| Molecular_info | Corresponding_CDS | F22D3.2c | |||||||
| F22D3.2d | |||||||||
| F22D3.2e | |||||||||
| F22D3.2f | |||||||||
| F22D3.2g | |||||||||
| F22D3.2i | |||||||||
| F22D3.2j | |||||||||
| Corresponding_CDS_history | F22D3.2:wp127 | ||||||||
| F22D3.2a:wp206 | |||||||||
| F22D3.2a:wp238 | |||||||||
| F22D3.2a:wp274 | |||||||||
| F22D3.2b:wp206 | |||||||||
| F22D3.2b:wp238 | |||||||||
| F22D3.2h:wp274 | |||||||||
| Corresponding_transcript | F22D3.2c.1 | ||||||||
| F22D3.2d.1 | |||||||||
| F22D3.2e.1 | |||||||||
| F22D3.2f.1 | |||||||||
| F22D3.2g.1 | |||||||||
| F22D3.2i.1 | |||||||||
| F22D3.2j.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (63) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00013748 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00045306 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013747 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031265 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092437 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092428 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr10985 | ||||||||
| Expr13864 | |||||||||
| Expr1017397 | |||||||||
| Expr1037596 | |||||||||
| Expr1149230 | |||||||||
| Expr2011814 | |||||||||
| Expr2030052 | |||||||||
| Drives_construct | WBCnstr00017598 | ||||||||
| WBCnstr00017614 | |||||||||
| WBCnstr00027093 | |||||||||
| Construct_product | WBCnstr00017614 | ||||||||
| WBCnstr00027093 | |||||||||
| WBCnstr00040219 | |||||||||
| Regulate_expr_cluster | WBPaper00042236:flcn-1(ok975)_upregulated | ||||||||
| WBPaper00056471:flcn-1(ok975)_downregulated | |||||||||
| WBPaper00056471:flcn-1(ok975)_upregulated | |||||||||
| Antibody | WBAntibody00002522 | ||||||||
| Microarray_results (41) | |||||||||
| Expression_cluster (164) | |||||||||
| Interaction | WBInteraction000402369 | ||||||||
| WBInteraction000520210 | |||||||||
| WBInteraction000520211 | |||||||||
| WBInteraction000520212 | |||||||||
| WBInteraction000520213 | |||||||||
| WBInteraction000520218 | |||||||||
| WBInteraction000521811 | |||||||||
| WBInteraction000534849 | |||||||||
| Map_info | Map | II | Position | 0.145905 | |||||
| Positive | Positive_clone | F22D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (10) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
