WormBase Tree Display for Gene: WBGene00017482
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| WBGene00017482 | SMap | S_parent | Sequence | F15E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | set-9 | Person_evidence | WBPerson1730 | |||||
| WBPerson268 | |||||||||
| WBPerson632 | |||||||||
| Sequence_name | F15E6.1 | ||||||||
| Molecular_name | F15E6.1 | ||||||||
| F15E6.1.1 | |||||||||
| CE48653 | |||||||||
| Other_name | CELE_F15E6.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | set-9 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 03 May 2007 10:33:07 | WBPerson2970 | Name_change | CGC_name | set-9 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | set | ||||||||
| Allele (179) | |||||||||
| Strain | WBStrain00027554 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00032541 | ||||||||
| 00032542 | |||||||||
| 00032543 | |||||||||
| 00032544 | |||||||||
| 00032545 | |||||||||
| 00032546 | |||||||||
| 00032547 | |||||||||
| 00032548 | |||||||||
| 00032549 | |||||||||
| 00032550 | |||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00013106 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022203 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WBGene00012845 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | set-9 encodes a large (1,655-residue) protein with a low-complexity N-terminal region, followed by a PHD-zinc finger and a SET domain; SET-9 has no non-nematode orthologs, but has 96% identity (1616/1679 residues) to its paralog SET-26; SET-9 is required for a normally short lifespan and low spontaneous mutation rate; life extension by set-9(RNAi) requires DAF-16, indicating that SET-9 limits normal lifespan by negatively regulating DAF-16 (either directly or indirectly); otherwise, neither set-9(n4949) nor set-9(RNAi) have any obvious phenotypes. | Paper_evidence | WBPaper00005736 | |||||
| WBPaper00026643 | |||||||||
| WBPaper00030864 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 11 Oct 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable histone methyltransferase activity and metal ion binding activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 23; esophagus squamous cell carcinoma; and prostate cancer. Is an ortholog of human SETD5 (SET domain containing 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25566) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25566) | ||||||
| DOID:0070053 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25566) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25566) | ||||||
| Molecular_info | Corresponding_CDS | F15E6.1 | |||||||
| Corresponding_CDS_history | F15E6.1:wp239 | ||||||||
| Corresponding_transcript | F15E6.1.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf660093 | ||||||||
| WBsf981738 | |||||||||
| WBsf228184 | |||||||||
| Transcription_factor | WBTranscriptionFactor000774 | ||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr9865 | ||||||||
| Expr14392 | |||||||||
| Expr14393 | |||||||||
| Expr1019881 | |||||||||
| Expr1037519 | |||||||||
| Expr1148706 | |||||||||
| Expr2015783 | |||||||||
| Expr2034016 | |||||||||
| Regulate_expr_cluster | WBPaper00054410:set-9(rw5)_downregulated | ||||||||
| WBPaper00054410:set-9(rw5)_upregulated | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | IV | Position | 0.147586 | |||||
| Positive | Positive_clone | F15E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
