WormBase Tree Display for Gene: WBGene00017482

WBGene00017482 SMap: S_parent: Sequence: F15E6
  Identity: Version: 2
    Name: CGC_name: set-9 Person_evidence: WBPerson1730
            WBPerson268
            WBPerson632
      Sequence_name: F15E6.1
      Molecular_name: F15E6.1
        F15E6.1.1
        CE48653
      Other_name: CELE_F15E6.1 Accession_evidence: NDB BX284604
      Public_name: set-9
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 May 2007 10:33:07 WBPerson2970 Name_change: CGC_name: set-9
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: set
    Allele: WBVar02148993
      WBVar01452163
      WBVar02049105
      WBVar02036867
      WBVar02052459
      WBVar01498795
      WBVar00316620
      WBVar00304386
      WBVar02053799
      WBVar02133736
      WBVar02133737
      WBVar02133738
      WBVar00299994
      WBVar02133739
      WBVar01727453
      WBVar01727454
      WBVar02048239
      WBVar01515467
      WBVar01966225
      WBVar01515468
      WBVar00090906
      WBVar01515469
      WBVar01515470
      WBVar02096191
      WBVar01515471
      WBVar01515472
      WBVar01515473
      WBVar00572238
      WBVar01668723
      WBVar01668724
      WBVar01668725
      WBVar01710235
      WBVar01668726
      WBVar01668727
      WBVar01481749
      WBVar01668728
      WBVar02003835
      WBVar01499790
      WBVar02020521
      WBVar02020522
      WBVar02020523
      WBVar02020524
      WBVar00298606
      WBVar01649720
      WBVar01649721
      WBVar01499800
      WBVar00903989
      WBVar00903990
      WBVar01568756
      WBVar01568757
      WBVar00903991
      WBVar00903992
      WBVar01568758
      WBVar00903993
      WBVar01568759
      WBVar01568760
      WBVar00903994
      WBVar00903995
      WBVar01568761
      WBVar01568762
      WBVar00903996
      WBVar01568763
      WBVar00903997
      WBVar00903998
      WBVar00306807
      WBVar01568764
      WBVar01568765
      WBVar00903999
      WBVar00904000
      WBVar01568766
      WBVar01499633
      WBVar00904001
      WBVar00904002
      WBVar00904003
      WBVar00244259
      WBVar00904004
      WBVar00904005
      WBVar00904006
      WBVar00904007
      WBVar00904008
      WBVar02073342
      WBVar00904009
      WBVar00904010
      WBVar00904011
      WBVar01581130
      WBVar00904012
      WBVar00904013
      WBVar00904014
      WBVar00904015
      WBVar00904016
      WBVar01846916
      WBVar00904017
      WBVar00904018
      WBVar00904019
      WBVar00904020
      WBVar00904021
      WBVar00904022
      WBVar00904023
      WBVar00904024
      WBVar00188633
      WBVar00904025
      WBVar00188634
      WBVar00904026
      WBVar00188635
      WBVar00904027
      WBVar01953688
      WBVar00904028
      WBVar01953689
      WBVar01953690
      WBVar00904029
      WBVar00302026
      WBVar00904030
      WBVar01953691
      WBVar01953692
      WBVar00904031
      WBVar01953693
      WBVar00904032
      WBVar00904033
      WBVar01953694
      WBVar00904034
      WBVar00904035
      WBVar00904036
      WBVar00423108
      WBVar00904037
      WBVar00423109
      WBVar00904038
      WBVar00423110
      WBVar00904039
      WBVar00423111
      WBVar00904040
      WBVar01923159
      WBVar00423112
      WBVar00423113
      WBVar00904041
      WBVar01923160
      WBVar01923161
      WBVar00423114
      WBVar00904042
      WBVar00423115
      WBVar00904043
      WBVar01923162
      WBVar00423116
      WBVar00904044
      WBVar01923163
      WBVar01923164
      WBVar00904045
      WBVar00423117
      WBVar00904046
      WBVar00423118
      WBVar00423119
      WBVar00904047
      WBVar01794630
      WBVar00904048
      WBVar00423120
      WBVar00904049
      WBVar00423121
      WBVar00904050
      WBVar02097944
      WBVar00423122
      WBVar01910824
      WBVar00904051
      WBVar00423123
      WBVar01990829
      WBVar00904052
      WBVar00423124
      WBVar01990830
      WBVar00423125
      WBVar00904053
      WBVar01990831
      WBVar00904054
      WBVar01990832
      WBVar02114881
      WBVar00904055
      WBVar01630658
      WBVar01630659
      WBVar01630660
      WBVar01825773
      WBVar01786325
      WBVar02113052
    Strain: WBStrain00027554
    RNASeq_FPKM (74)
    GO_annotation: 00032541
      00032542
      00032543
      00032544
      00032545
      00032546
      00032547
      00032548
      00032549
      00032550
    Ortholog (29)
    Paralog: WBGene00013106 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00022203 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00012845 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: set-9 encodes a large (1,655-residue) protein with a low-complexity N-terminal region, followed by a PHD-zinc finger and a SET domain; SET-9 has no non-nematode orthologs, but has 96% identity (1616/1679 residues) to its paralog SET-26; SET-9 is required for a normally short lifespan and low spontaneous mutation rate; life extension by set-9(RNAi) requires DAF-16, indicating that SET-9 limits normal lifespan by negatively regulating DAF-16 (either directly or indirectly); otherwise, neither set-9(n4949) nor set-9(RNAi) have any obvious phenotypes. Paper_evidence: WBPaper00005736
            WBPaper00026643
            WBPaper00030864
          Curator_confirmed: WBPerson567
          Date_last_updated: 11 Oct 2007 00:00:00
      Automated_description: Predicted to enable histone methyltransferase activity and metal ion binding activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 23; esophagus squamous cell carcinoma; and prostate cancer. Is an ortholog of human SETD5 (SET domain containing 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25566)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25566)
      DOID:0070053 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25566)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25566)
  Molecular_info: Corresponding_CDS: F15E6.1
    Corresponding_CDS_history: F15E6.1:wp239
    Corresponding_transcript: F15E6.1.1
    Other_sequence (12)
    Associated_feature: WBsf660093
      WBsf981738
      WBsf228184
    Transcription_factor: WBTranscriptionFactor000774
  Experimental_info: RNAi_result (29)
    Expr_pattern: Expr9865
      Expr14392
      Expr14393
      Expr1019881
      Expr1037519
      Expr1148706
      Expr2015783
      Expr2034016
    Regulate_expr_cluster: WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054410:set-9(rw5)_upregulated
    Microarray_results (19)
    Expression_cluster (149)
    Interaction (17)
  Map_info: Map: IV Position: 0.147586
    Positive: Positive_clone: F15E6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene