upb-1 encodes the C. elegans ortholog of 3-ureidopropionase; UPB-1 exhibits enzymatic activity in vitro, catalyzing the catabolism of 3-ureidopropionate and 2-methyl-3-ureidopropionate; a UPB-1::GFP fusion is expressed throughout larval development and in adults; UPB-1::GFP localizes to the dense body of striated body wall muscles, suggesting that UPB-1 may play a role in synthesis of carnosin-like dipeptides.
Enables beta-ureidopropionase activity. Involved in beta-alanine biosynthetic process via 3-ureidopropionate; thymine catabolic process; and uracil catabolic process. Located in striated muscle dense body. Expressed in body wall musculature. Is an ortholog of human UPB1 (beta-ureidopropionase 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.