WormBase Tree Display for Gene: WBGene00017241

WBGene00017241 SMap: S_parent: Sequence: F08C6
  Identity: Version: 2
    Name: CGC_name: pcyt-1 Person_evidence: WBPerson1711
      Sequence_name: F08C6.2
      Molecular_name: F08C6.2a
        F08C6.2a.1
        CE30937
        F08C6.2b
        CE39144
        F08C6.2b.1
      Other_name: CELE_F08C6.2 Accession_evidence: NDB BX284606
      Public_name: pcyt-1
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 20 Apr 2011 10:05:24 WBPerson2970 Name_change: CGC_name: pcyt-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pcyt
    Allele (156)
    Strain: WBStrain00031168
      WBStrain00037474
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00051297 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00036598 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00156000 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00127560 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00223452 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2375 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g8082 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g14220 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g19967 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g2879 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g2880 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8135 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g1710 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6100 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g7637 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g20822 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00783.g14115 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-pcyt-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g12431 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00054.g2729 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00142 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024810 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01521 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g16809 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0208100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19436 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239860 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304995 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00264921 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000003434 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0035231 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0041342 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050417-108 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050522-114 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-051120-48 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-061220-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:8754 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:8755 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:88557 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2147987 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:70515 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:708434 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00017878 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00021215 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016531 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021352 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: pcyt-1 encodes a lipid-activated CTP:phosphocholine cytidylyltransferase (CCT), with CCT activity in vitro; recombinant PCYT-1 is most activated by a 1:1 mixture of phosphatidylcholine:oleate vesicles; an inhibitory 21-residue segment (residues 246-266) is critical for specific activation of PCYT-1 by lipids, since deletion or mutation of this segment causes PCYT-1 to be constitutively active without its normal lipid substrate. Paper_evidence: WBPaper00004651
            WBPaper00004877
            WBPaper00005654
            WBPaper00035321
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Oct 2011 00:00:00
      Automated_description: Enables choline-phosphate cytidylyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Expressed in head. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Is an ortholog of human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112300 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8754)
  Molecular_info: Corresponding_CDS: F08C6.2a
      F08C6.2b
    Corresponding_CDS_history: F08C6.2:wp149
    Corresponding_transcript: F08C6.2a.1
      F08C6.2b.1
    Other_sequence (77)
    Associated_feature (20)
  Experimental_info: RNAi_result (34)
    Expr_pattern (7)
    Drives_construct: WBCnstr00002991
      WBCnstr00027460
    Construct_product: WBCnstr00027460
    Microarray_results (25)
    Expression_cluster (177)
    Interaction (73)
  Map_info: Map: X Position: -1.49196
    Positive: Positive_clone: F08C6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Picture: WBPicture0000013096
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene