WormBase Tree Display for Gene: WBGene00017195
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| WBGene00017195 | SMap | S_parent | Sequence | F07C3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | glo-4 | Person_evidence | WBPerson253 | |||||
| Sequence_name | F07C3.4 | ||||||||
| Molecular_name | F07C3.4 | ||||||||
| F07C3.4.1 | |||||||||
| CE47730 | |||||||||
| Other_name | CELE_F07C3.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | glo-4 | ||||||||
| DB_info | Database | AceView | gene | 5J716 | |||||
| WormQTL | gene | WBGene00017195 | |||||||
| WormFlux | gene | WBGene00017195 | |||||||
| NDB | locus_tag | CELE_F07C3.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00017195|UniProtKB=Q5DX34 | |||||||
| family | PTHR45622 | ||||||||
| NCBI | gene | 179306 | |||||||
| RefSeq | protein | NM_072991.5 | |||||||
| SwissProt | UniProtAcc | Q5DX34 | |||||||
| TREEFAM | TREEFAM_ID | TF329478 | |||||||
| UniProt_GCRP | UniProtAcc | Q5DX34 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 25 Apr 2005 11:39:03 | WBPerson2970 | Name_change | CGC_name | glo-4 | ||||
| 3 | 20 Oct 2005 09:00:52 | WBPerson1849 | Event | Acquires_merge | WBGene00017196 | ||||
| Acquires_merge | WBGene00017196 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glo | ||||||||
| Allele (90) | |||||||||
| Strain | WBStrain00031524 | ||||||||
| WBStrain00034033 | |||||||||
| WBStrain00034036 | |||||||||
| WBStrain00034037 | |||||||||
| WBStrain00034043 | |||||||||
| WBStrain00034045 | |||||||||
| WBStrain00005440 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00081284 | ||||||||
| 00081285 | |||||||||
| 00081286 | |||||||||
| 00081287 | |||||||||
| 00081288 | |||||||||
| 00081289 | |||||||||
| 00081290 | |||||||||
| 00081291 | |||||||||
| 00081292 | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00004304 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00010768 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012370 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | glo-4 encodes a guanine nucleotide exchange factor (GEF) that is similar to Drosophila Claret and human RP3; throughout development, glo-4 activity is required for biogenesis of the lysosome-related gut granules; based upon phenotypic similarity, glo-4 is likely to encode a GEF for the GLO-1 Rab-like GTPase; in regulating gut granule formation, glo-4 acts downstream of apb-3, which encodes the AP-3 complex beta subunit. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00025094 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 23 Jan 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of axon extension. Located in axon and synapse. Expressed in body wall musculature; intestine; muscle cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in atherosclerosis. Is an ortholog of human SERGEF (secretion regulating guanine nucleotide exchange factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17499) | ||||
| Molecular_info | Corresponding_CDS | F07C3.4 | |||||||
| Corresponding_CDS_history | F07C3.4:wp138 | ||||||||
| F07C3.4:wp232 | |||||||||
| Corresponding_transcript | F07C3.4.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf669206 | ||||||||
| WBsf669207 | |||||||||
| WBsf669208 | |||||||||
| WBsf1000841 | |||||||||
| WBsf234207 | |||||||||
| WBsf234208 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr172 | ||||||||
| Expr4951 | |||||||||
| Expr4952 | |||||||||
| Expr1020477 | |||||||||
| Expr1037391 | |||||||||
| Expr1147854 | |||||||||
| Expr2012108 | |||||||||
| Expr2030344 | |||||||||
| Drives_construct | WBCnstr00000702 | ||||||||
| WBCnstr00012364 | |||||||||
| WBCnstr00027491 | |||||||||
| Construct_product | WBCnstr00012364 | ||||||||
| WBCnstr00027491 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (26) | |||||||||
| Map_info | Map | V | Position | 1.95446 | Error | 0.001141 | |||
| Positive | Positive_clone | F07C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5191 | |||||||
| 5601 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (30) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
