WormBase Tree Display for Gene: WBGene00016625
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WBGene00016625 | SMap | S_parent | Sequence | C44B7 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | aff-1 | Person_evidence | WBPerson3851 | |||||
WBPerson493 | |||||||||
Sequence_name | C44B7.3 | ||||||||
Molecular_name | C44B7.3 | ||||||||
C44B7.3.1 | |||||||||
CE41369 | |||||||||
Other_name | CELE_C44B7.3 | Accession_evidence | NDB | BX284602 | |||||
Public_name | aff-1 | ||||||||
DB_info | Database | AceView | gene | 2H152 | |||||
WormQTL | gene | WBGene00016625 | |||||||
WormFlux | gene | WBGene00016625 | |||||||
NDB | locus_tag | CELE_C44B7.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00016625|UniProtKB=G5EGL9 | |||||||
family | PTHR37415 | ||||||||
NCBI | gene | 174123 | |||||||
RefSeq | protein | NM_063001.6 | |||||||
SwissProt | UniProtAcc | G5EGL9 | |||||||
TREEFAM | TREEFAM_ID | TF318705 | |||||||
UniProt_GCRP | UniProtAcc | G5EGL9 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 03 May 2007 10:33:07 | WBPerson2970 | Name_change | CGC_name | aff-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | aff | ||||||||
Reference_allele | WBVar00266475 | Paper_evidence | WBPaper00029363 | ||||||
Allele (26) | |||||||||
Strain | WBStrain00003881 | ||||||||
WBStrain00000197 | |||||||||
WBStrain00003884 | |||||||||
WBStrain00003885 | |||||||||
WBStrain00003886 | |||||||||
WBStrain00047003 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00020506 | ||||||||
00020507 | |||||||||
00020508 | |||||||||
00020509 | |||||||||
00020510 | |||||||||
00020511 | |||||||||
00020512 | |||||||||
00020513 | |||||||||
00020514 | |||||||||
00020515 | |||||||||
Ortholog (25) | |||||||||
Paralog | WBGene00001159 | Caenorhabditis elegans | From_analysis (3) | ||||||
WBGene00023420 | Caenorhabditis elegans | From_analysis (3) | |||||||
Structured_description | Concise_description | aff-1 encodes a cell-surface protein required in late L4 larvae forvarious cell fusions, of which at least one (AC-utse) does not requireEFF-1; in vulval development, AFF-1 is required for fusion of the anchorcell (AC) with the utse syncytium, of A cells to one another, and of Dcells to one another; AFF-1 is also required for lateral seam cellfusions; since aff-1 mutants fail to mix AC with utse cytoplasm, AFF-1is probably required to begin cell fusion by forming intercellularpores; AFF-1 has no obvious non-nematode orthologs, but is paralogous toEFF-1 and C26D10.7; AFF-1 is predicted to be largely extracellular, witheight conserved predicted disulfide bonds in its ectodomain and a singleC-terminal transmembrane domain; AFF-1 is expressed in the AC, beginningaround the AC's invasion of basement membrane in mid-L3 larvae, andcontinuing until the AC's fusion to utse; AFF-1 is also expressed inutse, beginning in L4 larvae, after which AC-utse fusion immediatelyensues; in both AC and utse, AFF-1 expression requires FOS-1, and theaff-1 promoter has predicted FOS-1 binding sites; other sites of AFF-1expression include embryonic hyp5 cells, pharyngeal muscles (Pm3 andPm5), head and tail neurons, sheath cells of chemosensory neurons, andmale tail neurons; subcellularly, AFF-1::GFP localizes to plasmamembrane and (undefined) intracellular organelles; generally, AFF-1 isexpressed in cells whose fusion does not require EFF-1, which mayexplain why AFF-1 and EFF-1 are redundantly required for viability; heatshock-driven overexpression of AFF-1, even in an eff-1 null mutantbackground, can induce ectopic cell fusion, and heterologous AFF-1 caninduce insect Sf9 cells to fuse in vitro. | Paper_evidence | WBPaper00029363 | |||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 04 Jun 2007 00:00:00 | ||||||||
Automated_description | Involved in regulation of egg-laying behavior and syncytium formation by plasma membrane fusion. Located in plasma membrane. Expressed in anchor cell; egg-laying apparatus; epithelial cell; neurons; and pharyngeal muscle cell. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C44B7.3 | |||||||
Corresponding_CDS_history | C44B7.3:wp88 | ||||||||
C44B7.3:wp179 | |||||||||
Corresponding_transcript | C44B7.3.1 | ||||||||
Associated_feature | WBsf717693 | ||||||||
WBsf988281 | |||||||||
WBsf988282 | |||||||||
WBsf988283 | |||||||||
WBsf1012448 | |||||||||
WBsf223240 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern (13) | |||||||||
Drives_construct | WBCnstr00000620 | ||||||||
WBCnstr00012152 | |||||||||
WBCnstr00012153 | |||||||||
WBCnstr00012510 | |||||||||
WBCnstr00013132 | |||||||||
WBCnstr00027928 | |||||||||
WBCnstr00040834 | |||||||||
WBCnstr00040835 | |||||||||
Construct_product | WBCnstr00008101 | ||||||||
WBCnstr00012152 | |||||||||
WBCnstr00012153 | |||||||||
WBCnstr00013132 | |||||||||
WBCnstr00015967 | |||||||||
WBCnstr00027928 | |||||||||
WBCnstr00040835 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (137) | |||||||||
Interaction | WBInteraction000188024 | ||||||||
WBInteraction000365196 | |||||||||
WBInteraction000502906 | |||||||||
WBInteraction000502907 | |||||||||
WBInteraction000503580 | |||||||||
WBInteraction000520686 | |||||||||
WBInteraction000520687 | |||||||||
Map_info | Map | II | Position | 0.125694 | Error | 0.001371 | |||
Positive | Positive_clone | C44B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (37) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |