WormBase Tree Display for Gene: WBGene00016408

WBGene00016408 SMap: S_parent: Sequence: C34E10
  Identity: Version: 3
    Name: CGC_name: prmt-5 Person_evidence: WBPerson4055
      Sequence_name: C34E10.5
      Molecular_name: C34E10.5
        C34E10.5.1
        CE29033
        C34E10.5.2
        C34E10.5.3
      Other_name: tag-251 Person_evidence: WBPerson201
        CELE_C34E10.5 Accession_evidence: NDB BX284603
      Public_name: prmt-5
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 20 Jul 2007 11:50:19 WBPerson2970 Name_change: CGC_name: prmt-5
        3 20 Jul 2007 11:50:19 WBPerson2970 Name_change: Other_name: tag-251
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: prmt
    Allele (48)
    Strain: WBStrain00036097
    RNASeq_FPKM (74)
    GO_annotation (42)
    Contained_in_operon: CEOP3268
    Ortholog (36)
    Structured_description: Automated_description: Enables DNA-binding transcription factor binding activity; p53 binding activity; and protein methyltransferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of DNA damage response, signal transduction by p53 class mediator; and response to odorant. Located in nucleus. Human ortholog(s) of this gene implicated in Leydig cell tumor and seminoma. Is an ortholog of human PRMT5 (protein arginine methyltransferase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2696 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10894)
      DOID:4440 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10894)
  Molecular_info: Corresponding_CDS: C34E10.5
    Corresponding_transcript: C34E10.5.1
      C34E10.5.2
      C34E10.5.3
    Other_sequence (21)
    Associated_feature (2)
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr1018696
      Expr1037030
      Expr1145902
      Expr2015099
      Expr2033337
    Drives_construct: WBCnstr00028094
    Construct_product: WBCnstr00028094
    Antibody: WBAntibody00002111
    Microarray_results (22)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045693:S.flexneri_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051311:VGLN-1-interacting
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_15
      WBPaper00025032:cluster_6
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00045673:colistin_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:intrinsic
    Interaction (111)
  Map_info: Map: III Position: -1.87136 Error: 0.010434
    Positive: Positive_clone: C34E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5207
        4167
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene