rig-6 encodes a protein with immunoglobulin and fibronectin type III domains and is similar to vertebrate contactins; based upon large-scale RNAi screens, rig-6 activity appears to be required for reproduction and positive regulation of body size; rig-6::gfp reporter fusion are expressed in neurons, particularly the URX ring interneurons.
Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including axon guidance; negative regulation of defecation rhythm; and regulation of locomotion. Located in axon; neuronal cell body; and synapse. Expressed in several structures, including body wall musculature; neurons; non-striated muscle; rectal epithelium; and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including Compton-North congenital myopathy; familial adult myoclonic epilepsy 5; and high grade glioma. Is an ortholog of human CNTN6 (contactin 6).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.