WormBase Tree Display for Gene: WBGene00016343
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| WBGene00016343 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | cnnm-3 | Person_evidence | WBPerson32343 | |||||
| WBPerson32344 | |||||||||
| Sequence_name | C33D12.2 | ||||||||
| Molecular_name (17) | |||||||||
| Other_name | CELE_C33D12.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | cnnm-3 | ||||||||
| DB_info | Database | AceView | gene | XD656 | |||||
| WormQTL | gene | WBGene00016343 | |||||||
| WormFlux | gene | WBGene00016343 | |||||||
| NDB | locus_tag | CELE_C33D12.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016343|UniProtKB=A0A131MCZ8 | |||||||
| family | PTHR12064 | ||||||||
| NCBI | gene | 180591 | |||||||
| RefSeq | protein | NM_001380926.1 | |||||||
| NM_001383539.1 | |||||||||
| NM_001383538.1 | |||||||||
| NM_001322613.3 | |||||||||
| SwissProt | UniProtAcc | A0A131MCZ8 | |||||||
| UniProt_GCRP | UniProtAcc | A0A131MCZ8 | |||||||
| OMIM | gene | 607803 | |||||||
| 607805 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Jan 2016 15:29:00 | WBPerson2970 | Name_change | CGC_name | cnnm-3 | ||||
| 3 | 18 Feb 2016 15:52:20 | WBPerson1983 | Event | Acquires_merge | WBGene00019737 | ||||
| Acquires_merge | WBGene00019737 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cnnm | ||||||||
| Allele (158) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00007255 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00011260 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016879 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019869 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | C33D12.2 encodes a predicted transmembrane protein orthologous to humanACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C01H6.6,C52D10.12, M02F4.3, R04E5.2, and R13G10.4; by orthology with MAM3,C33D12.2 may participate in metal homoeostasis; C33D12.2 is expressed inintestine, body wall muscle, nervous system (including ventral anddorsal nerve cords and head neurons), and adult vulval muscle andreproductive system; C33D12.2, MAM3, and ACDP1-ACDP4 belong to a familyof proteins (sharing an ACD domain) from bacteria, yeast, plants, andmetazoa; murine Acdp1 is a plasma membrane protein; bacterial proteinscontaining the ACD domain include CorC from Salmonella typhimurium,which is involved in magnesium and cobalt efflux; C33D12.2 has noobvious function in RNAi assays. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006525 | |||||||||
| WBPaper00013242 | |||||||||
| WBPaper00013325 | |||||||||
| WBPaper00013365 | |||||||||
| WBPaper00013531 | |||||||||
| WBPaper00028771 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 09 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of developmental process. Located in basolateral plasma membrane. Expressed in hypodermis and rectum. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Is an ortholog of several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3); and CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:103) | ||||
| EFO:MONDO:0014631 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:103) | ||||||
| DOID:0111404 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:105) | ||||||
| Molecular_info | Corresponding_CDS | C33D12.2a | |||||||
| C33D12.2b | |||||||||
| C33D12.2c | |||||||||
| C33D12.2d | |||||||||
| Corresponding_CDS_history | C33D12.2:wp223 | ||||||||
| C33D12.2:wp252 | |||||||||
| Corresponding_transcript | C33D12.2a.1 | ||||||||
| C33D12.2b.1 | |||||||||
| C33D12.2b.2 | |||||||||
| C33D12.2b.3 | |||||||||
| C33D12.2b.4 | |||||||||
| C33D12.2b.5 | |||||||||
| C33D12.2b.6 | |||||||||
| C33D12.2c.1 | |||||||||
| C33D12.2d.1 | |||||||||
| Associated_feature | WBsf653799 | ||||||||
| WBsf670270 | |||||||||
| WBsf670271 | |||||||||
| WBsf670272 | |||||||||
| WBsf1004508 | |||||||||
| WBsf1022561 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00011524 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00017129 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050824 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00093032 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017135 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041747 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017134 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034385 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1933 | ||||||||
| Expr5408 | |||||||||
| Expr13087 | |||||||||
| Expr1023685 | |||||||||
| Expr1027680 | |||||||||
| Expr1145768 | |||||||||
| Expr1154518 | |||||||||
| Expr2010279 | |||||||||
| Expr2028521 | |||||||||
| Drives_construct | WBCnstr00003593 | ||||||||
| WBCnstr00025635 | |||||||||
| WBCnstr00038578 | |||||||||
| WBCnstr00038579 | |||||||||
| Construct_product | WBCnstr00025635 | ||||||||
| WBCnstr00038578 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction | WBInteraction000548458 | ||||||||
| Map_info | Map | X | Position | -12.6467 | |||||
| Positive | Positive_clone | C33D12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00050045 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059396 | |||||||||
| WBPaper00060240 | |||||||||
| WBPaper00065331 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
