WormBase Tree Display for Gene: WBGene00016192
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| WBGene00016192 | SMap | S_parent | Sequence | C28H8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | bcl-7 | Person_evidence | WBPerson426 | |||||
| Sequence_name | C28H8.1 | ||||||||
| Molecular_name | C28H8.1 | ||||||||
| C28H8.1.1 | |||||||||
| CE01820 | |||||||||
| Other_name | CELE_C28H8.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | bcl-7 | ||||||||
| DB_info | Database | AceView | gene | 3H17 | |||||
| WormQTL | gene | WBGene00016192 | |||||||
| WormFlux | gene | WBGene00016192 | |||||||
| NDB | locus_tag | CELE_C28H8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016192|UniProtKB=Q09242 | |||||||
| family | PTHR12767 | ||||||||
| NCBI | gene | 175838 | |||||||
| RefSeq | protein | NM_065886.6 | |||||||
| SwissProt | UniProtAcc | Q09242 | |||||||
| TREEFAM | TREEFAM_ID | TF317441 | |||||||
| UniProt_GCRP | UniProtAcc | Q09242 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 20 May 2014 11:44:19 | WBPerson2970 | Name_change | CGC_name | bcl-7 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bcl | ||||||||
| Allele (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00053020 | ||||||||
| 00053021 | |||||||||
| 00053022 | |||||||||
| 00053023 | |||||||||
| 00053024 | |||||||||
| Ortholog (43) | |||||||||
| Structured_description | Concise_description | bcl-7 encodes the sole C. elegans member of the BCL7 family of proteins that contains human proteins, namely BCL7A and BCL7B, that are associated with malignant diseases; bcl-7 activity is required for proper terminal seam cell differentiation as well as for normal development of the distal tip cells of the somatic gonad and germ line; in controlling cell development and differentiation, bcl-7 interacts with the Wnt signaling pathway, regulating the asymmetric localization of WRM-1, and hence POP-1, in asymmetric cell divisions; bcl-7 may also function to regulate apoptosis, as loss of bcl-7 activity results in increased expression of ced-9; a BCL-7::GFP reporter is expressed ubiquitously and localized to nuclei; mammalian BCL7 family members are members of Swi/Snf transcriptional regulatory complexes. | Paper_evidence | WBPaper00046304 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 May 2014 00:00:00 | ||||||||
| Automated_description | Predicted to be involved in Wnt signaling pathway; apoptotic process; and cell differentiation. Predicted to be located in nucleus. Expressed in distal tip cell; germ cell; and gonadal sheath cell. Is an ortholog of human BCL7A (BAF chromatin remodeling complex subunit BCL7A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C28H8.1 | |||||||
| Corresponding_transcript | C28H8.1.1 | ||||||||
| Other_sequence | Acan_isotig14735 | ||||||||
| Oden_isotig13379 | |||||||||
| CBC13479_1 | |||||||||
| Tcir_isotig09201 | |||||||||
| CJC05531_1 | |||||||||
| Dviv_isotig33085 | |||||||||
| Tcol_contig20712 | |||||||||
| Oden_isotig13380 | |||||||||
| JI180958.1 | |||||||||
| Associated_feature | WBsf645222 | ||||||||
| WBsf645223 | |||||||||
| WBsf225029 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00061740 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114621 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029301 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011309 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005962 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076175 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041425 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12126 | ||||||||
| Expr1015868 | |||||||||
| Expr1036929 | |||||||||
| Expr1145455 | |||||||||
| Expr2009584 | |||||||||
| Expr2027821 | |||||||||
| Drives_construct | WBCnstr00008715 | ||||||||
| WBCnstr00020228 | |||||||||
| WBCnstr00020229 | |||||||||
| WBCnstr00028256 | |||||||||
| Construct_product | WBCnstr00008715 | ||||||||
| WBCnstr00020228 | |||||||||
| WBCnstr00020229 | |||||||||
| WBCnstr00028256 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (67) | |||||||||
| Map_info | Map | III | Position | -1.43385 | |||||
| Positive | Positive_clone | C28H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00032961 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00046304 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
