WormBase Tree Display for Gene: WBGene00016103
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| WBGene00016103 | SMap | S_parent | Sequence | C25F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dpyd-1 | |||||||
| Sequence_name | C25F6.3 | ||||||||
| Molecular_name | C25F6.3 | ||||||||
| C25F6.3.1 | |||||||||
| CE38489 | |||||||||
| Other_name | CELE_C25F6.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | dpyd-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 03 Aug 2007 17:23:44 | WBPerson2970 | Name_change | CGC_name | dpyd-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dpyd | ||||||||
| Allele (67) | |||||||||
| Strain | WBStrain00037841 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00012326 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00013376 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020932 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | dpyd-1 encodes the C. elegans ortholog of human DihydroPYrimidine Dehydrogenase (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270); DPYD-1 is the first and rate-limiting enzyme for uracil and thymine metabolism to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively, and in humans, functions in metabolism of the anti-cancer pyrimidine antagonist 5-fluorouracil (5-FU); in C. elegans, loss of dpyd-1 activity via RNAi results in sensitivity (decreased survival) to 5-FU while conversely, DPYD-1 overexpression affords increased germ cell survivability to 5-FU. | Paper_evidence | WBPaper00004637 | |||||
| WBPaper00013017 | |||||||||
| WBPaper00031988 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Jul 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) | ||||
| DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) | ||||||
| DOID:14218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) | ||||||
| DOID:3121 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) | ||||||
| Molecular_info | Corresponding_CDS | C25F6.3 | |||||||
| Corresponding_CDS_history | C25F6.3:wp142 | ||||||||
| Corresponding_transcript | C25F6.3.1 | ||||||||
| Other_sequence (74) | |||||||||
| Associated_feature | WBsf655176 | ||||||||
| WBsf662790 | |||||||||
| WBsf1005274 | |||||||||
| WBsf1022956 | |||||||||
| WBsf235726 | |||||||||
| WBsf235727 | |||||||||
| WBsf235728 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00041194 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Expr1024901 | ||||||||
| Expr1036877 | |||||||||
| Expr1145225 | |||||||||
| Expr2011080 | |||||||||
| Expr2029317 | |||||||||
| Drives_construct | WBCnstr00028324 | ||||||||
| Construct_product | WBCnstr00028324 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (191) | |||||||||
| Interaction (64) | |||||||||
| Map_info | Map | X | Position | -5.27561 | |||||
| Positive | Positive_clone | C25F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00013017 | ||||||||
| WBPaper00031988 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056904 | |||||||||
| WBPaper00062388 | |||||||||
| WBPaper00065140 | |||||||||
| WBPaper00065331 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
