WormBase Tree Display for Gene: WBGene00015418
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WBGene00015418 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | pac-1 | Person_evidence | WBPerson6440 | |||
WBPerson440 | |||||||
Sequence_name | C04D8.1 | ||||||
Molecular_name (18) | |||||||
Other_name | CEGAP | Accession_evidence | EMBL | U02289 | |||
CELE_C04D8.1 | Accession_evidence | NDB | BX284603 | ||||
Public_name | pac-1 | ||||||
DB_info | Database | AceView | gene | 3J607 | |||
WormQTL | gene | WBGene00015418 | |||||
WormFlux | gene | WBGene00015418 | |||||
NDB | locus_tag | CELE_C04D8.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00015418|UniProtKB=P34288 | |||||
family | PTHR23176 | ||||||
NCBI | gene | 176201 | |||||
RefSeq | protein | NM_001136361.5 | |||||
NM_001306726.3 | |||||||
NM_001306727.4 | |||||||
NM_001306725.3 | |||||||
NM_066476.7 | |||||||
NM_001306728.4 | |||||||
SwissProt | UniProtAcc | P34288 | |||||
TrEMBL | UniProtAcc | U4PM34 | |||||
U4PRC7 | |||||||
U4PBN0 | |||||||
U4PBA1 | |||||||
UniProt_GCRP | UniProtAcc | P34288 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Acquires_merge | WBGene00018372 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pac | ||||||
Allele (340) | |||||||
Strain | WBStrain00032310 | ||||||
WBStrain00007530 | |||||||
WBStrain00007531 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Contained_in_operon | CEOP3814 | ||||||
Ortholog (40) | |||||||
Paralog | WBGene00008006 | Caenorhabditis elegans | From_analysis | Panther | |||
Structured_description | Concise_description | pac-1 encodes a RhoGAP (Rho guanosine triphosphatase (GTPase) activating protein); in the embryo, PAC-1 is essential for establishment of radial (inner-outer) asymmetry and specifically, for differential localization of PAR-6, PAR-3, and PKC-3 to outer somatic cell surfaces devoid of cell-cell contacts; in regulating PAR protein localization, PAC-1 appears to act by spatially regulating activity of the CDC-42 Rho GTPase which can bind PAR-6 and is required, genetically, for PAR-6 localization to the outer cell surface; a PAC-1::GFP fusion protein expressed in the early embryo and in cultured embryos localizes to points of cell-cell contact. | Paper_evidence | WBPaper00031968 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 30 Jun 2008 00:00:00 | ||||||
Automated_description | Enables GTPase activator activity. Involved in Rho protein signal transduction; protein localization; and regulation of gastrulation. Located in cell junction. Expressed in anus; epithelial cell; hypodermis; pharynx; and pm7. Is an ortholog of human ARHGAP23 (Rho GTPase activating protein 23). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C04D8.1a | |||||
C04D8.1b | |||||||
C04D8.1d | |||||||
C04D8.1e | |||||||
C04D8.1f | |||||||
C04D8.1g | |||||||
Corresponding_CDS_history | C04D8.1:wp92 | ||||||
C04D8.1a:wp196 | |||||||
C04D8.1c:wp275 | |||||||
Corresponding_transcript | C04D8.1a.1 | ||||||
C04D8.1b.1 | |||||||
C04D8.1d.1 | |||||||
C04D8.1e.1 | |||||||
C04D8.1f.1 | |||||||
C04D8.1g.1 | |||||||
Other_sequence (24) | |||||||
Associated_feature (62) | |||||||
Experimental_info | RNAi_result | WBRNAi00010104 | Inferred_automatically | RNAi_primary | |||
WBRNAi00039589 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00058797 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00111060 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021621 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005915 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005216 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr68 | ||||||
Expr2035 | |||||||
Expr8161 | |||||||
Expr12368 | |||||||
Expr13517 | |||||||
Expr1016440 | |||||||
Expr1036597 | |||||||
Expr1143693 | |||||||
Expr2014677 | |||||||
Expr2032910 | |||||||
Drives_construct | WBCnstr00020487 | ||||||
WBCnstr00020494 | |||||||
WBCnstr00028863 | |||||||
Construct_product (16) | |||||||
Microarray_results (39) | |||||||
Expression_cluster (124) | |||||||
Interaction (75) | |||||||
Map_info | Map | III | Position | -0.25513 | Error | 0.000591 | |
Positive | Positive_clone | C04D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (16) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |