fbxl-1 encodes the sole C. elegans leucine-rich repeat (LRR)-type F-box protein that is equally related to mammalian FBXL2 and FBXL20; fbxl-1(RNAi) results in animals with altered defecation rhythm and decreased dauer formation upon treatment with dauer pheromone (daumone); an fbxl-1 promoter::gfp fusion is expressed in the anterior and posterior regions of the worm, specifically around the amphids and anal sphincter, respectively.
Involved in several processes, including dauer entry; defecation rhythm; and regulation of defecation rhythm. Located in perikaryon and plasma membrane bounded cell projection. Is an ortholog of human FBXL2 (F-box and leucine rich repeat protein 2) and FBXL20 (F-box and leucine rich repeat protein 20).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.