WormBase Tree Display for Gene: WBGene00014172
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| WBGene00014172 | SMap | S_parent | Sequence | ZK970 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | clpp-1 | Person_evidence | WBPerson530 | |||||
| Sequence_name | ZK970.2 | ||||||||
| Molecular_name | ZK970.2a | ||||||||
| ZK970.2a.1 | |||||||||
| CE02402 | |||||||||
| ZK970.2b | |||||||||
| CE43229 | |||||||||
| ZK970.2d | |||||||||
| CE47044 | |||||||||
| ZK970.2b.1 | |||||||||
| ZK970.2c | |||||||||
| ZK970.2d.1 | |||||||||
| Other_name | ClpP | Paper_evidence | WBPaper00048445 | ||||||
| CELE_ZK970.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | clpp-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 16 Feb 2007 14:39:36 | WBPerson2970 | Name_change | CGC_name | clpp-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clpp | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00033924 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP2476 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | clpp-1 encodes a mitochondrial protein, homologous to bacterial ClpP, required to initiate the stress response to unfolded mitochondrial proteins; as with its bacterial ortholog, CLPP-1 is predicted to be a proteolytic subunit of a Clp-like protease, with an N-terminal region required for mitochondrial localization, and a C-terminal region of ClpP similarity; in response to a mutation stressing mitochondria, clpp-1(RNAi) animals show reduced HSP-60 levels, inhibited nuclear translocation and hsp-60 activation by DVE-1, and aberrant mitochondrial morphology; CLPP-1 is biochemically inhibited by the ClpP inhibitor Z-LY-CMK and the peptide aldehyde MG132, and may also be blocked by them when injected in vivo; CLPP-1 is expressed in the intestine. | Paper_evidence | WBPaper00006395 | |||||
| WBPaper00025054 | |||||||||
| WBPaper00026980 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| WBPaper00031084 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 20 Nov 2007 00:00:00 | ||||||||
| Automated_description | Enables serine-type endopeptidase activity. Involved in mitochondrial unfolded protein response and proteolysis. Located in mitochondrial matrix. Expressed in intestine. Human ortholog(s) of this gene implicated in Perrault syndrome. Is an ortholog of human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050857 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2084) | ||||
| Molecular_info | Corresponding_CDS | ZK970.2a | |||||||
| ZK970.2b | |||||||||
| ZK970.2d | |||||||||
| Corresponding_transcript | ZK970.2c | ||||||||
| ZK970.2a.1 | |||||||||
| ZK970.2b.1 | |||||||||
| ZK970.2d.1 | |||||||||
| Other_sequence (46) | |||||||||
| Associated_feature | WBsf650493 | ||||||||
| WBsf650494 | |||||||||
| WBsf665267 | |||||||||
| WBsf223776 | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern | Chronogram309 | ||||||||
| Expr3790 | |||||||||
| Expr1027051 | |||||||||
| Expr1036348 | |||||||||
| Expr1163283 | |||||||||
| Expr2010250 | |||||||||
| Expr2028492 | |||||||||
| Drives_construct | WBCnstr00001075 | ||||||||
| WBCnstr00011661 | |||||||||
| WBCnstr00029252 | |||||||||
| Construct_product | WBCnstr00005166 | ||||||||
| WBCnstr00029252 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction (67) | |||||||||
| WBProcess | WBbiopr:00000077 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | II | Position | 2.35411 | Error | 0.003423 | |||
| Positive | Positive_clone | ZK970 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
