ZK550.4 encodes the C. elegans ortholog of the TFIIE alpha subunit; when expressed in vitro with the TFIIE beta subunit encoded by F54D5.11, the protein product of ZK550.4 supports transcription initiation; the protein products of ZK550.4 and F54D5.11 physically interact in vitro.
Predicted to enable RNA polymerase II complex binding activity. Involved in transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIE complex. Is an ortholog of human GTF2E1 (general transcription factor IIE subunit 1).