WormBase Tree Display for Gene: WBGene00013955
expand all nodes | collapse all nodes | view schema
| WBGene00013955 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | kri-1 | Person_evidence | WBPerson137 | |||||
| Sequence_name | ZK265.1 | ||||||||
| Molecular_name | ZK265.1a | ||||||||
| ZK265.1a.1 | |||||||||
| CE37865 | |||||||||
| ZK265.1b | |||||||||
| CE37866 | |||||||||
| ZK265.1b.1 | |||||||||
| Other_name | CELE_ZK265.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | kri-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 15 Sep 2004 14:36:01 | WBPerson1971 | Name_change | CGC_name | kri-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kri | ||||||||
| Allele (138) | |||||||||
| Strain | WBStrain00004908 | ||||||||
| WBStrain00004911 | |||||||||
| WBStrain00031903 | |||||||||
| WBStrain00004889 | |||||||||
| WBStrain00004892 | |||||||||
| WBStrain00004896 | |||||||||
| WBStrain00004905 | |||||||||
| WBStrain00004910 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00014051 | ||||||||
| 00014052 | |||||||||
| 00014053 | |||||||||
| 00014054 | |||||||||
| 00014055 | |||||||||
| 00014056 | |||||||||
| 00014057 | |||||||||
| 00014058 | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00001495 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00001496 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | kri-1 encodes an ankyrin repeat and FERM domain-containing protein orthologous to human KRIT1 (Krev interaction trapped/cerebral cavernous malformation 1, OMIM:604214); kri-1 was identified in RNAi screens for genes required for DAF-16-dependent lifespan extension in germline-depleted animals; subsequent analysis of kri-1 mutations suggests that KRI-1 is required for proper localization of DAF-16 in the intestine in response to germline loss; a rescuing KRI-1::GFP construct is expressed in larval and adult stages in pharyngeal and intestinal cells; the KRI-1::GFP is generally diffuse, but also localizes to apical and apicolateral cell surfaces as well as to intestinal nuclei in some animals. | Paper_evidence | WBPaper00027158 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Apr 2008 00:00:00 | ||||||||
| Automated_description | Involved in positive regulation of gene expression. Located in apical plasma membrane; apicolateral plasma membrane; and nucleus. Expressed in intestine and pharynx. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 1. Is an ortholog of human KRIT1 (KRIT1 ankyrin repeat containing). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060669 | Homo sapiens | Paper_evidence | WBPaper00059910 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Sep 2020 00:00:00 | ||||||||
| Potential_model | DOID:0060669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1573) | |||||
| DOID:0080491 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1573) | ||||||
| Models_disease_asserted | WBDOannot00000808 | ||||||||
| Molecular_info | Corresponding_CDS | ZK265.1a | |||||||
| ZK265.1b | |||||||||
| Corresponding_CDS_history | ZK265.1:wp136 | ||||||||
| Corresponding_transcript | ZK265.1a.1 | ||||||||
| ZK265.1b.1 | |||||||||
| Other_sequence | Oden_isotig10471 | ||||||||
| Oden_isotig10473 | |||||||||
| FG583776.1 | |||||||||
| Oden_isotig10472 | |||||||||
| Oden_isotig10470 | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr3841 | ||||||||
| Expr1017543 | |||||||||
| Expr1036238 | |||||||||
| Expr1162743 | |||||||||
| Expr2012980 | |||||||||
| Expr2031212 | |||||||||
| Drives_construct | WBCnstr00001012 | ||||||||
| WBCnstr00001013 | |||||||||
| WBCnstr00001014 | |||||||||
| WBCnstr00022940 | |||||||||
| WBCnstr00029417 | |||||||||
| Construct_product | WBCnstr00001012 | ||||||||
| WBCnstr00001013 | |||||||||
| WBCnstr00001014 | |||||||||
| WBCnstr00022940 | |||||||||
| WBCnstr00029417 | |||||||||
| Regulate_expr_cluster | WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated | ||||||||
| WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_upregulated | |||||||||
| WBPaper00056586:kri-1(ok1251)_downregulated | |||||||||
| WBPaper00056586:kri-1(ok1251)_upregulated | |||||||||
| WBPaper00056586:KRI-1_interacting | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (16) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | I | Position | 2.70099 | Error | 0.000625 | |||
| Positive | Positive_clone | ZK265 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4950 | |||||||
| 5076 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
