WormBase Tree Display for Gene: WBGene00013312

WBGene00013312 SMap: S_parent: Sequence: Y57G11C
  Identity: Version: 2
    Name: CGC_name: hhat-2 Person_evidence: WBPerson83
      Sequence_name: Y57G11C.17
      Molecular_name: Y57G11C.17a
        Y57G11C.17a.1
        CE39446
        Y57G11C.17b
      Other_name: CELE_Y57G11C.17 Accession_evidence: NDB BX284604
      Public_name: hhat-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 04 Mar 2005 10:23:45 WBPerson2970 Name_change: CGC_name: hhat-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hhat
    Allele (39)
    RNASeq_FPKM (74)
    GO_annotation: 00031828
      00031829
      00031830
      00031831
      00031832
    Ortholog (36)
    Paralog: WBGene00013852 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: hhat-2 encodes a putative protein-cysteine N-palmitoyltransferase ('hedgehog acyltransferase') orthologous to human HHAT (OMIM: 605743) and GUP1 (HHATL; OMIM:608116), and paralogous to HHAT-1; HHAT-2 is required for normal larval development and fat accumulation in mass RNAi assays; however, because C. elegans has no HEDGEHOG homolog, the substrate and function of HHAT-2 in vivo are unclear. Paper_evidence: WBPaper00005655
            WBPaper00024497
            WBPaper00027263
            WBPaper00031342
            WBPaper00032174
          Curator_confirmed: WBPerson567
          Date_last_updated: 14 Oct 2008 00:00:00
      Automated_description: Predicted to enable palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Is an ortholog of human HHAT (hedgehog acyltransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060644 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18270)
  Molecular_info: Corresponding_CDS: Y57G11C.17a
    Corresponding_transcript: Y57G11C.17b
      Y57G11C.17a.1
    Other_sequence (19)
    Associated_feature: WBsf231228
  Experimental_info: RNAi_result: WBRNAi00023369 Inferred_automatically: RNAi_primary
      WBRNAi00037596 Inferred_automatically: RNAi_primary
      WBRNAi00024245 Inferred_automatically: RNAi_primary
      WBRNAi00024169 Inferred_automatically: RNAi_primary
      WBRNAi00057689 Inferred_automatically: RNAi_primary
      WBRNAi00110938 Inferred_automatically: RNAi_primary
      WBRNAi00023882 Inferred_automatically: RNAi_primary
      WBRNAi00021137 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019075
      Expr1035939
      Expr1161101
      Expr2012411
      Expr2030647
    Drives_construct: WBCnstr00029693
    Construct_product: WBCnstr00029693
    Microarray_results (20)
    Expression_cluster (134)
    Interaction (15)
    WBProcess: WBbiopr:00000123
  Map_info: Map: IV Position: 12.5355 Error: 0.001902
    Positive: Positive_clone: Y57G11C Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027263
    WBPaper00038491
    WBPaper00055090
    WBPaper00064105
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene