WormBase Tree Display for Gene: WBGene00013132
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| WBGene00013132 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | strd-1 | Person_evidence | WBPerson2105 | |||||
| WBPerson542 | |||||||||
| Sequence_name | Y52D3.1 | ||||||||
| Molecular_name | Y52D3.1a | ||||||||
| Y52D3.1a.1 | |||||||||
| CE19223 | |||||||||
| Y52D3.1b | |||||||||
| Other_name | CELE_Y52D3.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | strd-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 11 May 2007 11:55:05 | WBPerson2970 | Name_change | CGC_name | strd-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | strd | ||||||||
| Allele (97) | |||||||||
| Strain | WBStrain00032462 | ||||||||
| WBStrain00032466 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Contained_in_operon | CEOP3708 | ||||||||
| Ortholog (34) | |||||||||
| Paralog (27) | |||||||||
| Structured_description | Concise_description | strd-1 encodes the C. elegans ortholog of the yeast STRAD STE-20-related pseudokinase and human STRAD alpha; STRD-1 functions cell autonomously in neurons, in a complex with the SAD-1 kinase, to regulate neuronal polarity and synaptic organization; unlike in vertebrates, STRD-1 appears to function independently of the PAR-4/LKB1 kinase in regulating neuronal polarity; strd-1; par-4 double mutants display decreased dauer life span, indicating that STRD-1 and PAR-4 also function to regulate long-term survival during the dauer diapause; STRD-1 activity is necessary for PAR-4 phosphorylation of the AMPK kinase to regulate germline stem cell quiescence; a strd-1::GFP promoter fusion is expressed in the pharynx, the excretory canal, and throughout the nervous system; in neurons, STRD-1 localizes to the nucleus, the cell body, and to neurites; specifically, STRD-1 co-localizes at synapses with the SAD-1 kinase, with which it physically interacts in vivo, and is required for SAD-1 localization. | Paper_evidence | WBPaper00032396 | |||||
| WBPaper00035545 | |||||||||
| WBPaper00035902 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Feb 2012 00:00:00 | ||||||||
| Automated_description | Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including asymmetric neuroblast division; maintenance of dauer; and positive regulation of peptidyl-threonine phosphorylation. Located in several cellular components, including cell body; cell cortex; and neuron projection. Expressed in excretory canal; nervous system; and pharynx. Is an ortholog of human STRADA (STE20 related adaptor alpha) and STRADB (STE20 related adaptor beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070511 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30172) | ||||
| Molecular_info | Corresponding_CDS | Y52D3.1a | |||||||
| Corresponding_transcript | Y52D3.1b | ||||||||
| Y52D3.1a.1 | |||||||||
| Other_sequence | Tcir_isotig20345 | ||||||||
| CBC03229_1 | |||||||||
| PT04688 | |||||||||
| CRC11635_1 | |||||||||
| CR08887 | |||||||||
| PT04549 | |||||||||
| Tcir_isotig18997 | |||||||||
| CJC13680_1 | |||||||||
| CR08888 | |||||||||
| Associated_feature | WBsf994199 | ||||||||
| WBsf225780 | |||||||||
| WBsf225781 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr8871 | ||||||||
| Expr1023994 | |||||||||
| Expr1035826 | |||||||||
| Expr1160666 | |||||||||
| Expr2017096 | |||||||||
| Expr2035232 | |||||||||
| Construct_product | WBCnstr00013575 | ||||||||
| Antibody | WBAntibody00002106 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (70) | |||||||||
| Interaction (14) | |||||||||
| Map_info | Map | III | Position | 5.70994 | Error | 0.022727 | |||
| Positive | Positive_clone | Y52D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
