WormBase Tree Display for Gene: WBGene00012394
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| WBGene00012394 | SMap | S_parent | Sequence | Y6B3B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | hsd-1 | Person_evidence | WBPerson2612 | |||||
| WBPerson370 | |||||||||
| Sequence_name | Y6B3B.11 | ||||||||
| Molecular_name | Y6B3B.11 | ||||||||
| Y6B3B.11.1 | |||||||||
| CE20185 | |||||||||
| Other_name | eak-2 | Paper_evidence | WBPaper00036004 | ||||||
| CELE_Y6B3B.11 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | hsd-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 03 Apr 2007 10:48:52 | WBPerson2970 | Name_change | CGC_name | hsd-1 | ||||
| 3 | 29 Mar 2010 10:16:19 | WBPerson2970 | Name_change | Other_name | eak-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsd | ||||||||
| Allele (75) | |||||||||
| Strain | WBStrain00007956 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP1918 | ||||||||
| Ortholog (37) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | hsd-1 encodes a hydroxysteroid dehydrogenase orthologous to 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases (3beta-HSDs); HSD-1 likely functions in the biosynthesis of steroid hormones, such as delta4-dafachronic acid, to promote reproductive growth (larval development) and prevent dauer arrest; in regulating larval development, hsd-1 exhibits cross-talk with the insulin signaling pathway, via regulation of the subcellular localization, and hence activity, of DAF-16; hsd-1 is expressed in the two neuronal-like XXX(L/R) cells beginning in late embryogenesis (pretzel stage) and continuing through all four larval stages, with expression fading in adults; HSD-1 is paralogous to HSD-2 and HSD-3. | Paper_evidence | WBPaper00031897 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Mar 2010 00:00:00 | ||||||||
| Automated_description | Enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity. Involved in nematode larval development and sterol biosynthetic process. Predicted to be located in membrane. Expressed in XXXL and XXXR. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Is an ortholog of human SDR42E1 (short chain dehydrogenase/reductase family 42E, member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111822 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13398) | ||||
| DOID:0111898 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13398) | ||||||
| Molecular_info | Corresponding_CDS | Y6B3B.11 | |||||||
| Corresponding_transcript | Y6B3B.11.1 | ||||||||
| Associated_feature | WBsf132696 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00058090 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00004780 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092591 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8098 | ||||||||
| Expr1010756 | |||||||||
| Expr1161503 | |||||||||
| Expr2012606 | |||||||||
| Expr2030842 | |||||||||
| Drives_construct | WBCnstr00013111 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (28) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | I | Position | 21.6434 | Error | 0.003332 | |||
| Positive | Positive_clone | Y6B3B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
