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WormBase Tree Display for Gene: WBGene00012342

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Name Class

WBGene00012342SMapS_parentSequenceW08D2
IdentityVersion2
NameCGC_namemtr-4Person_evidenceWBPerson699
WBPerson6229
Sequence_nameW08D2.7
Molecular_nameW08D2.7
W08D2.7.1
CE06562
Other_nameCELE_W08D2.7Accession_evidenceNDBBX284604
Public_namemtr-4
DB_infoDatabaseAceViewgene4K593
WormQTLgeneWBGene00012342
WormFluxgeneWBGene00012342
NDBlocus_tagCELE_W08D2.7
PanthergeneCAEEL|WormBase=WBGene00012342|UniProtKB=Q23223
familyPTHR12131
NCBIgene177824
RefSeqproteinNM_069356.6
SwissProtUniProtAccQ23223
TREEFAMTREEFAM_IDTF300597
UniProt_GCRPUniProtAccQ23223
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
204 Jun 2007 15:54:19WBPerson2970Name_changeCGC_namemtr-4
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmtr
AlleleWBVar02157927
WBVar00298702
WBVar00598768
WBVar01500079
WBVar00432907
WBVar00432908
WBVar00432909
WBVar00432910
WBVar00432911
WBVar01498996
WBVar02134472
WBVar02067846
WBVar01499925
WBVar01499770
WBVar01499771
WBVar00934171
WBVar00934172
WBVar00934173
WBVar00934174
WBVar00934175
WBVar00934176
WBVar00934177
WBVar00934178
WBVar00934179
WBVar02123820
WBVar00300053
WBVar00934180
WBVar00934181
WBVar00934182
WBVar00934183
WBVar00934184
WBVar00934185
WBVar00934186
WBVar00934187
WBVar00934188
WBVar00934189
WBVar00934190
WBVar00934191
WBVar00934192
WBVar00934193
WBVar00934194
WBVar00093753
WBVar00934195
WBVar00934196
WBVar00934197
WBVar00934198
WBVar01856317
WBVar01856318
WBVar00934199
WBVar01856319
WBVar01786465
WBVar02058536
WBVar01730486
WBVar01500038
WBVar01896603
WBVar01500039
WBVar00573996
WBVar01500245
Possibly_affected_byWBVar02153240
WBVar02153242
StrainWBStrain00002572
WBStrain00032681
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (43)
ParalogWBGene00008502Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012896Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00013189Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00016194Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00020964Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021905Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionmtr-4 encodes the C. elegans homolog of Saccharomyces cerevisiae Mtr4p, an RNA helicase that functions as part of the TRAMP complex that regulates polyadenylation of mRNAs destined for decay or exosomal trimming; loss of mtr-4 activity results in a variety of defects, including defects in germ line development; MTR-4 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo.Paper_evidenceWBPaper00040686
WBPaper00032961
Curator_confirmedWBPerson1843
Date_last_updated23 Jan 2012 00:00:00
Automated_descriptionPredicted to enable RNA helicase activity. Predicted to be involved in RNA catabolic process and maturation of 5.8S rRNA. Predicted to be located in nucleus. Expressed in PVDL; PVDR; embryonic cell; and somatic cell. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is an ortholog of human MTREX (Mtr4 exosome RNA helicase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:332Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18734)
Molecular_infoCorresponding_CDSW08D2.7
Corresponding_transcriptW08D2.7.1
Other_sequence (60)
Associated_featureWBsf646257
WBsf228881
Experimental_infoRNAi_result (30)
Expr_patternChronogram744
Expr6854
Expr12216
Expr12227
Expr15665
Expr1011473
Expr1035462
Expr1158512
Expr2013816
Expr2032056
Drives_constructWBCnstr00003134
WBCnstr00020415
WBCnstr00029987
Construct_productWBCnstr00020470
WBCnstr00029987
WBCnstr00042026
WBCnstr00042029
Microarray_resultsSMD_W08D2.7
SMD_W08D2.7:2
173343_s_at
193145_at
A_12_P115991
Aff_W08D2.7
GPL13394_WBGene00012342
GPL13914_W08D2.7
GPL14144_W08D2.7_401-460_0.806_105_A
GPL14144_W08D2.7_583-642_0.793_122_B
GPL14144_W08D2.7_759-818_0.782_140_C
GPL19516_CGZ0038792
GPL21109_W08D2.7
GPL3518_CE06562
GPL8304_CE_WBGene00012342_A
GPL8304_CE_WBGene00012342_B
GPL8304_CE_WBGene00012342_C
GPL8673_W08D2_7P01609
GPL8673_W08D2_7P02108
GPL8673_W08D2_7P02840
GPL9450_W08D2.7
cea2.p.100182
Expression_cluster (126)
Interaction (193)
Map_infoMapIVPosition4.42878Error0.000727
PositivePositive_cloneW08D2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00032961
WBPaper00038491
WBPaper00046432
WBPaper00055090
WBPaper00060530
WBPaper00064201
WBPaper00065012
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene