WormBase Tree Display for Gene: WBGene00011923
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| WBGene00011923 | SMap | S_parent | Sequence | T22C8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | chhy-1 | Paper_evidence | WBPaper00031658 | |||||
| Sequence_name | T22C8.2 | ||||||||
| Molecular_name | T22C8.2 | ||||||||
| T22C8.2.1 | |||||||||
| CE02350 | |||||||||
| T22C8.2.2 | |||||||||
| T22C8.2.3 | |||||||||
| Other_name | hya-1 | Paper_evidence | WBPaper00036418 | ||||||
| CSHY | Paper_evidence | WBPaper00042009 | |||||||
| CELE_T22C8.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | chhy-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 12 Jan 2009 13:35:00 | WBPerson2970 | Name_change | CGC_name | chhy-1 | ||||
| 3 | 06 Jun 2016 13:29:23 | WBPerson2970 | Name_change | Other_name | hya-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | chhy | ||||||||
| Allele (59) | |||||||||
| Strain | WBStrain00032957 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00011612 | ||||||||
| 00011613 | |||||||||
| 00011614 | |||||||||
| 00011615 | |||||||||
| 00011616 | |||||||||
| 00011617 | |||||||||
| 00011618 | |||||||||
| 00011619 | |||||||||
| 00119128 | |||||||||
| 00119129 | |||||||||
| Ortholog (64) | |||||||||
| Structured_description | Concise_description | chhy-1 encodes a chondroitin hydrolase orthologous to human HYAL1 (OMIM:607071, mutated in mucopolysaccharidosis type IX) and other hyaluronidases; in COS-7 cells, heterologously expressed CHHY-1 preferentially cleaves chondroitin as an endo-ss-galactosaminidase, with lesser activity on chondroitin sulfate A (CS-A) and CS-C, but almost no activity on hyaluronic acid; the optimum pH for CHHY-1 cleavage is 6.0. | Paper_evidence | WBPaper00031658 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Feb 2011 00:00:00 | ||||||||
| Automated_description | Enables hexosaminidase activity. Involved in chondroitin sulfate catabolic process. Expressed in PLML; PLMR; head; intestinal cell; and vulva. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IX. Is an ortholog of human HYAL2 (hyaluronidase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5320) | ||||
| DOID:12798 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5320) | ||||||
| Molecular_info | Corresponding_CDS | T22C8.2 | |||||||
| Corresponding_transcript | T22C8.2.1 | ||||||||
| T22C8.2.2 | |||||||||
| T22C8.2.3 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf988776 | ||||||||
| WBsf1012717 | |||||||||
| WBsf223523 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00053815 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00019012 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12841 | ||||||||
| Expr1017872 | |||||||||
| Expr1157362 | |||||||||
| Expr2009969 | |||||||||
| Expr2028209 | |||||||||
| Drives_construct | WBCnstr00023030 | ||||||||
| WBCnstr00030278 | |||||||||
| Construct_product | WBCnstr00030278 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction | WBInteraction000113772 | ||||||||
| WBInteraction000125516 | |||||||||
| WBInteraction000348387 | |||||||||
| WBInteraction000356867 | |||||||||
| WBInteraction000453207 | |||||||||
| Map_info | Map | II | Position | 0.827223 | Error | 0.00036 | |||
| Positive | Positive_clone | T22C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031658 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042009 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
