WormBase Tree Display for Gene: WBGene00011674
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| WBGene00011674 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyp-13A8 | |||||||
| Sequence_name | T10B9.4 | ||||||||
| Molecular_name | T10B9.4 | ||||||||
| T10B9.4.1 | |||||||||
| CE13541 | |||||||||
| Other_name | CELE_T10B9.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cyp-13A8 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-13A8 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (29) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00079953 | ||||||||
| 00079954 | |||||||||
| 00079955 | |||||||||
| 00118907 | |||||||||
| 00118908 | |||||||||
| 00118909 | |||||||||
| 00118910 | |||||||||
| Ortholog (84) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | cyp-13A8 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; loss of cyp-13A8 activity in large-scale RNAi screens results in low levels of embryonic lethality, sluggish locomotion, and a clear appearance. | Paper_evidence | WBPaper00005654 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:8552 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||
| DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11609) | ||||||
| DOID:2987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2637) | ||||||
| DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:0112251 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11609) | ||||||
| DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2637) | ||||||
| Molecular_info | Corresponding_CDS | T10B9.4 | |||||||
| Corresponding_transcript | T10B9.4.1 | ||||||||
| Other_sequence | MI04235 | ||||||||
| MI01651 | |||||||||
| ES743048.1 | |||||||||
| PPC00382_1 | |||||||||
| MIC02148_1 | |||||||||
| Associated_feature | WBsf650463 | ||||||||
| WBsf989152 | |||||||||
| WBsf1012907 | |||||||||
| WBsf1012908 | |||||||||
| WBsf1012909 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00035423 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00053018 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094897 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092626 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009149 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr15175 | ||||||||
| Expr1027602 | |||||||||
| Expr1156618 | |||||||||
| Expr2010688 | |||||||||
| Expr2028927 | |||||||||
| Drives_construct | WBCnstr00030479 | ||||||||
| WBCnstr00042031 | |||||||||
| Construct_product | WBCnstr00030479 | ||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | II | Position | 1.72429 | Error | 0.00034 | |||
| Positive | Positive_clone | T10B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00042257 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064073 | |||||||||
| WBPaper00064598 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
