WormBase Tree Display for Gene: WBGene00011433
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| WBGene00011433 | SMap | S_parent | Sequence | T04D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pde-1 | Person_evidence | WBPerson433 | |||||
| Sequence_name | T04D3.3 | ||||||||
| Molecular_name | T04D3.3a | ||||||||
| T04D3.3a.1 | |||||||||
| CE16340 | |||||||||
| T04D3.3b | |||||||||
| CE42925 | |||||||||
| T04D3.3b.1 | |||||||||
| Other_name | CELE_T04D3.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | pde-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 10 Dec 2004 15:16:09 | WBPerson2970 | Name_change | CGC_name | pde-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pde | ||||||||
| Allele (135) | |||||||||
| Strain | WBStrain00032846 | ||||||||
| WBStrain00034936 | |||||||||
| WBStrain00036917 | |||||||||
| WBStrain00036924 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00008443 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00011146 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020114 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022389 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016328 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pde-1 encodes one of six C. elegans cyclic nucleotide phosphodiesterases; PDE-1 is most closely related to the calcium/calmodulin (CaM)-dependent phosphodiesterases and binds bovine calmodulin in vitro in a calcium-dependent manner. | Paper_evidence | WBPaper00031011 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 May 2010 00:00:00 | ||||||||
| Automated_description | Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and response to alkaline pH. Expressed in AFDL; AFDR; and head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Is an ortholog of human PDE1A (phosphodiesterase 1A) and PDE1B (phosphodiesterase 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112165 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8776) | ||||
| Molecular_info | Corresponding_CDS | T04D3.3a | |||||||
| T04D3.3b | |||||||||
| Corresponding_transcript | T04D3.3a.1 | ||||||||
| T04D3.3b.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00004126 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052390 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001209 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035138 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1009 | ||||||||
| Expr6607 | |||||||||
| Expr12920 | |||||||||
| Expr14911 | |||||||||
| Expr1012958 | |||||||||
| Expr1035031 | |||||||||
| Expr1156015 | |||||||||
| Expr2014794 | |||||||||
| Expr2033028 | |||||||||
| Drives_construct | WBCnstr00003181 | ||||||||
| WBCnstr00023094 | |||||||||
| WBCnstr00030660 | |||||||||
| Construct_product | WBCnstr00023094 | ||||||||
| WBCnstr00030660 | |||||||||
| WBCnstr00041579 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (159) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | I | Position | 17.674 | Error | 0.012589 | |||
| Positive | Positive_clone | T04D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
