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WormBase Tree Display for Gene: WBGene00011195

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Name Class

WBGene00011195SMapS_parentSequenceR10D12
IdentityVersion2
NameCGC_namesao-1Paper_evidenceWBPaper00040544
Person_evidenceWBPerson215
Sequence_nameR10D12.14
Molecular_name (18)
Other_nameCELE_R10D12.14Accession_evidenceNDBBX284605
Public_namesao-1
DB_infoDatabaseAceViewgene5O445
WormQTLgeneWBGene00011195
WormFluxgeneWBGene00011195
NDBlocus_tagCELE_R10D12.14
NCBIgene3565237
RefSeqproteinNM_001047686.4
NM_001373150.2
NM_001392643.1
NM_001269621.3
NM_001269622.3
NM_001373151.3
SwissProtUniProtAccC6KRN1
TREEFAMTREEFAM_IDTF343597
TrEMBLUniProtAccA0A486WVM9
A0A486WV16
UniProt_GCRPUniProtAccC6KRN1
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:52WBPerson1971EventImportedInitial conversion from CDS class of WS125
206 Jan 2012 13:49:20WBPerson2970EventAcquires_mergeWBGene00004722
Name_changeCGC_namesao-1
Acquires_mergeWBGene00004722
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsao
Allele (38)
StrainWBStrain00033104
WBStrain00037410
WBStrain00000045
WBStrain00000047
RNASeq_FPKM (74)
GO_annotation00006943
00006944
00006945
00006946
00006947
00006948
00006949
00006950
00006951
Contained_in_operonCEOP5408
Ortholog (24)
Structured_descriptionConcise_descriptionsao-1 encodes a novel GYF domain-containing protein that is conserved amongst nematodes; maternally provided SAO-1 functions together with SEL-10, a component of an E3 ubiquitin ligase with which it physically interacts, to negatively regulate the Notch receptor signaling pathway in the early embryo; mutations in sao-1 also suppress early cytokinesis defects in rfl-1 mutant embryos (rfl-1 encodes an E1 activating enzyme in the protein neddylation pathway); a SAO-1::GFP fusion protein localizes to the cytoplasm, cell cortex, and cleavage furrow.Paper_evidenceWBPaper00040544
WBPaper00033469
Curator_confirmedWBPerson1843
Date_last_updated10 Jan 2012 00:00:00
Automated_descriptionEnables WD40-repeat domain binding activity. Involved in negative regulation of Notch signaling pathway and regulation of protein deneddylation. Located in cell cortex and cleavage furrow.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSR10D12.14a
R10D12.14b
R10D12.14c
R10D12.14d
R10D12.14e
R10D12.14f
Corresponding_transcriptR10D12.14a.1
R10D12.14b.1
R10D12.14c.1
R10D12.14d.1
R10D12.14e.1
R10D12.14f.1
Other_sequenceDviv_isotig33092
CBC01150_1
CJC00575_1
DN190290.1
AAC00271_1
CBC06467_1
Acan_isotig19145
Associated_featureWBsf662063
WBsf232853
Experimental_infoRNAi_resultWBRNAi00051681Inferred_automaticallyRNAi_primary
WBRNAi00017691Inferred_automaticallyRNAi_primary
WBRNAi00007689Inferred_automaticallyRNAi_primary
WBRNAi00034812Inferred_automaticallyRNAi_primary
WBRNAi00076609Inferred_automaticallyRNAi_primary
Expr_patternExpr8729
Expr1024355
Expr1034916
Expr1155356
Expr2015593
Expr2033828
Drives_constructWBCnstr00030855
Construct_productWBCnstr00007589
WBCnstr00013487
WBCnstr00030855
Microarray_results (26)
Expression_cluster (109)
SAGE_tagSAGE:gtcgtaagccStrandSense
Unambiguously_mapped
SAGE:gtcgtaagccacaccatStrandSense
Unambiguously_mapped
Interaction (814)
WBProcessWBbiopr:00000032
WBbiopr:00000072
Map_infoMapVPosition5.86244
PositivePositive_cloneR10D12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00026132
WBPaper00033469
WBPaper00034933
WBPaper00040544
WBPaper00043670
WBPaper00064644
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene