WormBase Tree Display for Gene: WBGene00011095
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WBGene00011095 | SMap | S_parent | Sequence | R07B7 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | gana | ||||||
Allele (28) | |||||||
Strain | WBStrain00002061 | ||||||
WBStrain00033052 | |||||||
WBStrain00052080 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (44) | |||||||
Structured_description | Concise_description | gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes. the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency. | Paper_evidence | WBPaper00004637 | |||
WBPaper00024995 | |||||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 13 Jul 2007 00:00:00 | ||||||
Automated_description | Predicted to enable alpha-galactosidase activity. Involved in glycoside catabolic process. Located in cytoplasm. Expressed in coelomocyte. Used to study Fabry disease. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schindler disease (multiple); and angiokeratoma. Is an ortholog of human GLA (galactosidase alpha) and NAGA (alpha-N-acetylgalactosaminidase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14499 | Homo sapiens | Paper_evidence | WBPaper00024995 | ||
Accession_evidence | OMIM | 301500 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Mar 2013 00:00:00 | ||||||
Potential_model (5) | |||||||
Disease_relevance | Elegans gana-1 is orthologous to the human NAGA and GALA genes; the human gene Alpha-N-acetylgalactosaminidase (NAGA, also known as GALB) is a lysosomal glycohydrolase, that cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates; mutations in GALB have been associated with Schindler disease type I and III and Kanzaki disease; mutations in human alpha-galactosidase (GLA), a lysosomal hydrolase are associated with Fabry disease. | Homo sapiens | Paper_evidence | WBPaper00031904 | |||
WBPaper00024995 | |||||||
Accession_evidence | OMIM | 609242 | |||||
609241 | |||||||
301500 | |||||||
300644 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 08 May 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000117 | ||||||
Molecular_info | Corresponding_CDS | R07B7.11 | |||||
Corresponding_transcript | R07B7.11.1 | ||||||
Other_sequence (42) | |||||||
Associated_feature | WBsf661853 | ||||||
WBsf232594 | |||||||
WBsf232595 | |||||||
Experimental_info | RNAi_result | WBRNAi00034684 | Inferred_automatically | RNAi_primary | |||
WBRNAi00017514 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00051428 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00061279 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1180 | ||||||
Expr3168 | |||||||
Expr6474 | |||||||
Expr6475 | |||||||
Expr1010714 | |||||||
Expr1034872 | |||||||
Expr1155117 | |||||||
Expr2011940 | |||||||
Expr2030177 | |||||||
Drives_construct | WBCnstr00002845 | ||||||
WBCnstr00004440 | |||||||
WBCnstr00011188 | |||||||
WBCnstr00030937 | |||||||
Construct_product | WBCnstr00011188 | ||||||
WBCnstr00016579 | |||||||
WBCnstr00016580 | |||||||
WBCnstr00030937 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (196) | |||||||
Interaction | WBInteraction000123322 | ||||||
WBInteraction000396593 | |||||||
WBInteraction000416572 | |||||||
WBInteraction000504156 | |||||||
WBInteraction000551639 | |||||||
Map_info | Map | V | Position | 3.62659 | Error | 0.001183 | |
Positive | Positive_clone | R07B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00024995 | ||||||
WBPaper00038491 | |||||||
WBPaper00042257 | |||||||
WBPaper00055090 | |||||||
WBPaper00064161 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |