WormBase Tree Display for Gene: WBGene00010722
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| WBGene00010722 | SMap | S_parent | Sequence | K09E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | Sequence_name | K09E4.4 | |||||||
| Molecular_name | K09E4.4 | ||||||||
| K09E4.4.1 | |||||||||
| CE32692 | |||||||||
| K09E4.4.2 | |||||||||
| Other_name | CELE_K09E4.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | K09E4.4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Allele (237) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | K09E4.4 is orthologous to the human gene Alpha-N-acetylglucosaminidase (NAGLU). | Curator_confirmed | WBPerson324 | |||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 May 2013 00:00:00 | ||||||||
| Automated_description | Enriched in neurons; retrovesicular ganglion; and somatic gonad precursor based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and clk-1 based on microarray; RNA-seq; and proteomic studies. Is affected by ten chemicals including rotenone; allantoin; and Sirolimus based on RNA-seq and microarray studies. Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V and mucopolysaccharidosis type IIIB. Is predicted to encode a protein with the following domains: Glycoside hydrolase superfamily; Alpha-N-acetylglucosaminidase; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Alpha-N-acetylglucosaminidase, tim-barrel domain; Alpha-N-acetylglucosaminidase, C-terminal; and Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Is an ortholog of human NAGLU (N-acetyl-alpha-glucosaminidase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:12798 | Homo sapiens | Paper_evidence | WBPaper00035542 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Mar 2023 00:00:00 | ||||||||
| Potential_model | DOID:0111394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7632) | |||||
| DOID:0110178 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7632) | ||||||
| DOID:12801 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7632) | ||||||
| Disease_relevance | Mutations in human Alpha-N-acetylglucosaminidase (NAGLU; orthologous to elegans K09E4.4), which catalyzes the stepwise degradation of heparan sulfate, are associated with Mucopolysaccharidosis type IIIB, also known as Sanfilippo syndrome B. | Homo sapiens | Accession_evidence | OMIM | 252920 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 May 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000169 | ||||||||
| Molecular_info | Corresponding_CDS | K09E4.4 | |||||||
| Corresponding_CDS_history | K09E4.4:wp91 | ||||||||
| Corresponding_transcript | K09E4.4.1 | ||||||||
| K09E4.4.2 | |||||||||
| Other_sequence | FG351075.1 | ||||||||
| FG350186.1 | |||||||||
| SS00119 | |||||||||
| SSC05618_1 | |||||||||
| FG580054.1 | |||||||||
| FG349350.1 | |||||||||
| FG347319.1 | |||||||||
| CBC04799_1 | |||||||||
| Associated_feature | WBsf650734 | ||||||||
| WBsf990633 | |||||||||
| WBsf990634 | |||||||||
| WBsf990635 | |||||||||
| WBsf990636 | |||||||||
| WBsf990637 | |||||||||
| WBsf1013782 | |||||||||
| WBsf1013783 | |||||||||
| WBsf1013784 | |||||||||
| WBsf224245 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00034210 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00103450 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016921 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098159 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050433 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1012015 | ||||||||
| Expr1034692 | |||||||||
| Expr1154137 | |||||||||
| Expr2004980 | |||||||||
| Expr2023201 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (161) | |||||||||
| Interaction | WBInteraction000231212 | ||||||||
| WBInteraction000347766 | |||||||||
| Map_info | Positive | Positive_clone | K09E4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | II | 22.4411 | |||||||
| Reference | WBPaper00035539 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065331 | |||||||||
| Method | Gene |
