WormBase Tree Display for Gene: WBGene00010722
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WBGene00010722 | SMap | S_parent | Sequence | K09E4 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Allele (237) | |||||||
RNASeq_FPKM (74) | |||||||
Ortholog (30) | |||||||
Structured_description | Concise_description | K09E4.4 is orthologous to the human gene Alpha-N-acetylglucosaminidase (NAGLU). | Curator_confirmed | WBPerson324 | |||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 06 May 2013 00:00:00 | ||||||
Automated_description | Enriched in neurons; retrovesicular ganglion; and somatic gonad precursor based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and clk-1 based on microarray; RNA-seq; and proteomic studies. Is affected by ten chemicals including rotenone; allantoin; and Sirolimus based on RNA-seq and microarray studies. Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V and mucopolysaccharidosis type IIIB. Is predicted to encode a protein with the following domains: Glycoside hydrolase superfamily; Alpha-N-acetylglucosaminidase; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Alpha-N-acetylglucosaminidase, tim-barrel domain; Alpha-N-acetylglucosaminidase, C-terminal; and Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Is an ortholog of human NAGLU (N-acetyl-alpha-glucosaminidase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:12798 | Homo sapiens | Paper_evidence | WBPaper00035542 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 13 Mar 2023 00:00:00 | ||||||
Potential_model | DOID:0111394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7632) | |||
DOID:0110178 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7632) | ||||
DOID:12801 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7632) | ||||
Disease_relevance | Mutations in human Alpha-N-acetylglucosaminidase (NAGLU; orthologous to elegans K09E4.4), which catalyzes the stepwise degradation of heparan sulfate, are associated with Mucopolysaccharidosis type IIIB, also known as Sanfilippo syndrome B. | Homo sapiens | Accession_evidence | OMIM | 252920 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 May 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000169 | ||||||
Molecular_info | Corresponding_CDS | K09E4.4 | |||||
Corresponding_CDS_history | K09E4.4:wp91 | ||||||
Corresponding_transcript | K09E4.4.1 | ||||||
K09E4.4.2 | |||||||
Other_sequence | FG351075.1 | ||||||
FG350186.1 | |||||||
SS00119 | |||||||
SSC05618_1 | |||||||
FG580054.1 | |||||||
FG349350.1 | |||||||
FG347319.1 | |||||||
CBC04799_1 | |||||||
Associated_feature | WBsf650734 | ||||||
WBsf990633 | |||||||
WBsf990634 | |||||||
WBsf990635 | |||||||
WBsf990636 | |||||||
WBsf990637 | |||||||
WBsf1013782 | |||||||
WBsf1013783 | |||||||
WBsf1013784 | |||||||
WBsf224245 | |||||||
Experimental_info | RNAi_result | WBRNAi00034210 | Inferred_automatically | RNAi_primary | |||
WBRNAi00103450 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00016921 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098159 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00050433 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1012015 | ||||||
Expr1034692 | |||||||
Expr1154137 | |||||||
Expr2004980 | |||||||
Expr2023201 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (161) | |||||||
Interaction | WBInteraction000231212 | ||||||
WBInteraction000347766 | |||||||
Map_info | Positive | Positive_clone | K09E4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Interpolated_map_position | II | 22.4411 | |||||
Reference | WBPaper00035539 | ||||||
WBPaper00038491 | |||||||
WBPaper00055090 | |||||||
WBPaper00065331 | |||||||
Method | Gene |