WormBase Tree Display for Gene: WBGene00010556
expand all nodes | collapse all nodes | view schema
| WBGene00010556 | SMap | S_parent | Sequence | K04D7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | rack-1 | Person_evidence | WBPerson3215 | |||||
| WBPerson598 | |||||||||
| Sequence_name | K04D7.1 | ||||||||
| Molecular_name | K04D7.1 | ||||||||
| K04D7.1.1 | |||||||||
| CE06090 | |||||||||
| K04D7.1.2 | |||||||||
| K04D7.1.3 | |||||||||
| Other_name | CELE_K04D7.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | rack-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 06 Apr 2006 09:26:55 | WBPerson2970 | Name_change | CGC_name | rack-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rack | ||||||||
| Allele (33) | |||||||||
| Strain | WBStrain00024150 | ||||||||
| WBStrain00037622 | |||||||||
| WBStrain00054763 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Contained_in_operon | CEOP4360 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | rack-1 encodes a seven-WD repeat-containing protein that is the C. elegans ortholog of vertebrate Receptor for Activated C Kinase (Rack1); rack-1 is required cell autonomously for VD/DD motor axon pathfinding; rack-1 is also required for gonadal distal tip cell migration and for normal brood sizes; genetic analyses indicate that rack-1 functions in the same pathway with ced-10/Rac and unc-115/abLIM, and in parallel to mig-2/RhoG and unc-34/Enabled, to control axon pathfinding; in regulating axon pathfinding, RACK-1 likely acts upstream of UNC-115 with which it physically interacts; rack-1 also acts downstream of, or with, unc-115 to regulate P cell nuclear migration; in regulating gonadal distal tip cell migration, rack-1 acts either independently of, or in the same pathway as, ced-10 and mig-2; rack-1::gfp is expressed in most, if not all, tissues, and a RACK-1::GFP localizes to the cytoplasm, with some fusion protein also seen in the axons, cell bodies, and growth cones of migrating VD neurons. | Paper_evidence | WBPaper00037834 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Jun 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein kinase C binding activity and ribosome binding activity. Involved in several processes, including antifungal innate immune response; cytoskeleton-dependent cytokinesis; and motor neuron axon guidance. Located in several cellular components, including centrosome; growth cone; and kinetochore. Expressed in anterior distal tip cell; neurons; and posterior distal tip cell. Is an ortholog of human RACK1 (receptor for activated C kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K04D7.1 | |||||||
| Corresponding_transcript | K04D7.1.1 | ||||||||
| K04D7.1.2 | |||||||||
| K04D7.1.3 | |||||||||
| Other_sequence (387) | |||||||||
| Associated_feature | WBsf047611 | ||||||||
| WBsf646290 | |||||||||
| WBsf660560 | |||||||||
| WBsf660561 | |||||||||
| WBsf660562 | |||||||||
| WBsf660563 | |||||||||
| WBsf660564 | |||||||||
| WBsf228950 | |||||||||
| WBsf228951 | |||||||||
| WBsf228952 | |||||||||
| Experimental_info | RNAi_result (76) | ||||||||
| Expr_pattern | Expr3619 | ||||||||
| Expr9167 | |||||||||
| Expr9168 | |||||||||
| Expr1019890 | |||||||||
| Expr1034606 | |||||||||
| Expr1153600 | |||||||||
| Expr2015237 | |||||||||
| Expr2033471 | |||||||||
| Drives_construct | WBCnstr00013763 | ||||||||
| WBCnstr00013764 | |||||||||
| WBCnstr00031328 | |||||||||
| Construct_product | WBCnstr00011544 | ||||||||
| WBCnstr00013764 | |||||||||
| WBCnstr00022524 | |||||||||
| WBCnstr00022526 | |||||||||
| WBCnstr00031328 | |||||||||
| Antibody | WBAntibody00001960 | ||||||||
| WBAntibody00002548 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (180) | |||||||||
| Interaction (282) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | IV | Position | 4.55595 | Error | 0.000352 | |||
| Positive | Positive_clone | K04D7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (38) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
