Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and single-stranded DNA 3'-5' DNA exonuclease activity. Predicted to be involved in DNA metabolic process and mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Human ortholog(s) of this gene implicated in ascending colon cancer; carcinoma (multiple); and mismatch repair cancer syndrome. Is an ortholog of human POLE (DNA polymerase epsilon, catalytic subunit).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.