WormBase Tree Display for Gene: WBGene00009323

WBGene00009323 SMap: S_parent: Sequence: F32B6
  Identity: Version: 2
    Name: CGC_name: best-13 Person_evidence: WBPerson260
      Sequence_name: F32B6.9
      Molecular_name: F32B6.9
        F32B6.9.1
        CE09864
      Other_name: CELE_F32B6.9 Accession_evidence: NDB BX284604
      Public_name: best-13
    DB_info: Database: AceView gene 4K667
        WormQTL gene WBGene00009323
        WormFlux gene WBGene00009323
        NDB locus_tag CELE_F32B6.9
        Panther gene CAEEL|WormBase=WBGene00009323|UniProtKB=O45435
          family PTHR10736
        NCBI gene 185198
        RefSeq protein NM_069383.4
        SwissProt UniProtAcc O45435
        UniProt_GCRP UniProtAcc O45435
        OMIM gene 607854
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 07 Feb 2012 16:30:56 WBPerson2970 Name_change: CGC_name: best-13
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: best
    Allele (15)
    Strain: WBStrain00003647
    RNASeq_FPKM (74)
    GO_annotation: 00034505
      00034506
      00034507
      00034508
      00034509
      00034510
      00034511
      00034512
      00034513
      00117043
    Ortholog (46)
    Paralog (26)
    Structured_description: Automated_description: Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Expressed in vulB1; vulB2; vulC; vulD; and vulE. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy and retinal degeneration (multiple). Is an ortholog of several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110396 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0050661 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0050662 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0111569 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
  Molecular_info: Corresponding_CDS: F32B6.9
    Corresponding_transcript: F32B6.9.1
    Other_sequence (23)
    Associated_feature: WBsf997500
      WBsf997501
      WBsf997502
      WBsf997503
      WBsf997504
      WBsf1018019
      WBsf228901
  Experimental_info: RNAi_result: WBRNAi00031670 Inferred_automatically: RNAi_primary
      WBRNAi00014211 Inferred_automatically: RNAi_primary
      WBRNAi00046120 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr5932
      Expr12306
      Expr1010990
      Expr1034076
      Expr1150003
      Expr2009595
      Expr2027832
    Drives_construct: WBCnstr00004087
      WBCnstr00032286
    Construct_product: WBCnstr00032286
    Microarray_results (22)
    Expression_cluster: WBPaper00033070:Elbe_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045521:Gender_Neutral
      WBPaper00046121:ecdoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00048988:neuron_expressed
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061340:AMsh
      WBPaper00061340:AMso
      WBPaper00061340:Excretory_cell
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:hyp3
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:M_cell
      WBPaper00061340:XXX
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:cdc-42_17192-rab-5_18073
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:27_0
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4489_group_20
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_5
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00035227:heat_shock_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037695:LD_DD_6-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(143_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction: WBInteraction000357675
  Map_info: Map: IV Position: 4.4443
    Positive: Positive_clone: F32B6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00033469
    WBPaper00038491
    WBPaper00040183
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene