WormBase Tree Display for Gene: WBGene00008748
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| WBGene00008748 | SMap | S_parent | Sequence | F13E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | yap-1 | Paper_evidence | WBPaper00041976 | |||||
| Person_evidence | WBPerson3250 | ||||||||
| Sequence_name | F13E6.4 | ||||||||
| Molecular_name | F13E6.4 | ||||||||
| F13E6.4.1 | |||||||||
| CE37348 | |||||||||
| Other_name | CELE_F13E6.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | yap-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 15 Mar 2013 16:30:53 | WBPerson2970 | Name_change | CGC_name | yap-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | yap | ||||||||
| Allele (62) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (28) | |||||||||
| Structured_description | Concise_description | yap-1 encodes a protein with sequence similarity to YAP (yes-associated protein) in its N-terminal TEAD-binding domain and WW domain; YAP-1 plays a role in the response to heat and in determination of adult life span; YAP-1 physically interacts with EGL-44, a transcription enhancer factor of the TEA domain (TEAD) class, and when co-expressed, the two proteins are able to activate a TEAD reporter; YAP-1 also physically interacts with WTS-1, the C. elegans LATS ortholog; YAP-1 is broadly expressed throughout development and found in a number of different tissues including epithelia, hypodermis, muscles, pharynx, intestine, gonadal sheath cells, vulval, and the spermatheca; YAP-1 mainly localizes to the cytoplasm and, during specific developmental events, to the nucleus; YAP-1 cytoplasmic localization is regulated by WTS-1, and the 14-3-3 protein FTT-2; in response to heat, YAP-1 transiently accumulates in the nucleus, with subsequent translocation to the cytoplasm dependent on the DAF-21 HSP90 and HSF-1 heat shock factor. | Paper_evidence | WBPaper00041976 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Mar 2013 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in establishment of cell polarity and positive regulation of transcription by RNA polymerase II. Located in axoneme; ciliary base; and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including excretory system; hermaphrodite gonad; pharyngeal muscle cell; tail hypodermis; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer and uveal coloboma-cleft lip and palate-intellectual disability. Is an ortholog of human WWTR1 (WW domain containing transcription regulator 1) and YAP1 (Yes1 associated transcriptional regulator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16262) | ||||
| DOID:0111249 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16262) | ||||||
| Molecular_info | Corresponding_CDS | F13E6.4 | |||||||
| Corresponding_CDS_history | F13E6.4:wp131 | ||||||||
| Corresponding_transcript | F13E6.4.1 | ||||||||
| Other_sequence | CR06128 | ||||||||
| CR10105 | |||||||||
| JI175645.1 | |||||||||
| JI182032.1 | |||||||||
| CRC05660_1 | |||||||||
| CBC03524_1 | |||||||||
| JI240353.1 | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00025093 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027276 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013227 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025092 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013226 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044515 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00032722 | ||||||||
| Construct_product | WBCnstr00016991 | ||||||||
| WBCnstr00016992 | |||||||||
| WBCnstr00032722 | |||||||||
| WBCnstr00039991 | |||||||||
| WBCnstr00041554 | |||||||||
| Regulate_expr_cluster | WBPaper00057136:yap-1(ys38)_downregulated | ||||||||
| WBPaper00057136:yap-1(ys38)_upregulated | |||||||||
| Antibody | WBAntibody00002402 | ||||||||
| WBAntibody00002403 | |||||||||
| WBAntibody00002916 | |||||||||
| WBAntibody00002917 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | X | Position | 2.37291 | |||||
| Positive | Positive_clone | F13E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
