WormBase Tree Display for Gene: WBGene00008385

WBGene00008385 SMap: S_parent: Sequence: D1081
  Identity: Version: 2
    Name: CGC_name: lotr-1 Person_evidence: WBPerson2113
      Sequence_name: D1081.7
      Molecular_name: D1081.7
        D1081.7.1
        CE41211
      Other_name: CELE_D1081.7 Accession_evidence: NDB BX284601
      Public_name: lotr-1
    DB_info: Database: AceView gene 1J65
        WormQTL gene WBGene00008385
        WormFlux gene WBGene00008385
        NDB locus_tag CELE_D1081.7
        NCBI gene 172638
        RefSeq protein NM_001128966.4
        TrEMBL UniProtAcc A5Z2T6
        UniProt_GCRP UniProtAcc A5Z2T6
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Jan 2021 22:55:32 WBPerson1983 Name_change: CGC_name: lotr-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lotr
    Allele (34)
    RNASeq_FPKM (74)
    Contained_in_operon: CEOP1929
    Ortholog (19)
    Structured_description: Automated_description: Enriched in ABalaaaala; ABalaapaaa; germ line; germline precursor cell; and head mesodermal cell based on proteomic; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-2; skn-1; and glp-1 based on microarray; RNA-seq; and proteomic studies. Is affected by fifteen chemicals including rotenone; manganese chloride; and D-glucose based on RNA-seq; proteomic; and microarray studies. Is predicted to encode a protein with the following domain: Phosphorylation site. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: D1081.7
    Corresponding_CDS_history: D1081.7a:wp246
    Corresponding_transcript: D1081.7.1
    Other_sequence: CBC07277_1
      CBC08291_1
      CRC00521_1
      CBC04203_1
      CR10591
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00030362 Inferred_automatically: RNAi_primary
      WBRNAi00066542 Inferred_automatically: RNAi_primary
      WBRNAi00003275 Inferred_automatically: RNAi_primary
      WBRNAi00066729 Inferred_automatically: RNAi_primary
      WBRNAi00043416 Inferred_automatically: RNAi_primary
      WBRNAi00007769 Inferred_automatically: RNAi_primary
      WBRNAi00077823 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1023645
      Expr1033633
      Expr1147403
      Expr2002048
      Expr2020270
    Drives_construct: WBCnstr00033006
    Construct_product: WBCnstr00033006
    Microarray_results (21)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00032425:up_in_lin-35
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038168:lin-35_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050193:lsm-1(tm3585)_upregulated_L3
      WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051310:LIN-41_interacting
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L1
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060886:met-2(n4256)_upregulated
      WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061199:GYF-1_interacting
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:AIN_parent
      WBPaper00061340:Germline
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:met-2(n4256)_upregulated
      WBPaper00062123:DEPS-1_interacting
      WBPaper00062123:GLH-1_interacting
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064163:ZNFX-1_interacting_young-adult
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_27
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037695:LD_3-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (329)
  Map_info: Positive: Positive_clone: D1081 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: I 2.86353
  Reference: WBPaper00057898
    WBPaper00063892
    WBPaper00064163
  Method: Gene