WormBase Tree Display for Gene: WBGene00008205
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| WBGene00008205 | SMap | S_parent | Sequence | C49F5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | sams-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | C49F5.1 | ||||||||
| Molecular_name | C49F5.1 | ||||||||
| C49F5.1.1 | |||||||||
| CE08852 | |||||||||
| C49F5.1.2 | |||||||||
| C49F5.1.3 | |||||||||
| Other_name | drop-4 | Paper_evidence | WBPaper00049625 | ||||||
| CELE_C49F5.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | sams-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 31 Aug 2005 14:07:05 | WBPerson2970 | Name_change | CGC_name | sams-1 | ||||
| 3 | 14 Jun 2016 13:25:45 | WBPerson2970 | Name_change | Other_name | drop-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sams | ||||||||
| Allele (73) | |||||||||
| Strain | WBStrain00032921 | ||||||||
| WBStrain00037189 | |||||||||
| WBStrain00037325 | |||||||||
| WBStrain00034121 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00006416 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00015540 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00015538 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sams-1 encodes an S-adenosyl methionine synthetase; by homology, SAMS-1 is predicted to function as a methyl-group donor in many biochemical reactions; sams-1 expression levels are negatively regulated by dietary restriction (as seen in eat-2 mutant animals), suggesting that increased lifespan due to dietary restriction is due, in part, to reducing the activity of key metabolic enzymes; loss of sams-1 via RNAi can extend adult lifespan. | Paper_evidence | WBPaper00026715 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Dec 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable methionine adenosyltransferase activity. Involved in negative regulation of lipid storage. Predicted to be located in cytosol. Expressed in body wall musculature; dorsal nerve cord; and ventral nerve cord. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Is an ortholog of human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:3146 | Homo sapiens | Paper_evidence | WBPaper00038215 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Mar 2021 00:00:00 | ||||||||
| Potential_model | DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6904) | |||||
| DOID:0050544 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6903) | ||||||
| Models_disease_asserted | WBDOannot00000888 | ||||||||
| Molecular_info | Corresponding_CDS | C49F5.1 | |||||||
| Corresponding_transcript | C49F5.1.1 | ||||||||
| C49F5.1.2 | |||||||||
| C49F5.1.3 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (61) | ||||||||
| Expr_pattern | Expr9199 | ||||||||
| Expr1020417 | |||||||||
| Expr1033564 | |||||||||
| Expr1146787 | |||||||||
| Expr2015586 | |||||||||
| Expr2033821 | |||||||||
| Drives_construct | WBCnstr00007957 | ||||||||
| WBCnstr00009291 | |||||||||
| WBCnstr00013788 | |||||||||
| WBCnstr00033157 | |||||||||
| Construct_product | WBCnstr00007957 | ||||||||
| WBCnstr00033157 | |||||||||
| Antibody | WBAntibody00001281 | ||||||||
| WBAntibody00002975 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (323) | |||||||||
| Interaction (158) | |||||||||
| Map_info | Map | X | Position | 6.79596 | Error | 0.017153 | |||
| Positive | Positive_clone | C49F5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (60) | |||||||||
| Picture | WBPicture0000013096 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
