WormBase Tree Display for Gene: WBGene00007653
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| WBGene00007653 | SMap | S_parent | Sequence | C17G1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cysl-1 | Paper_evidence | WBPaper00039977 | |||||
| Person_evidence | WBPerson537 | ||||||||
| Sequence_name | C17G1.7 | ||||||||
| Molecular_name | C17G1.7 | ||||||||
| C17G1.7.1 | |||||||||
| CE39223 | |||||||||
| Other_name | CELE_C17G1.7 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | cysl-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 29 Sep 2011 10:45:56 | WBPerson2970 | Name_change | CGC_name | cysl-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cysl | ||||||||
| Allele (48) | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (22) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | cysl-1 encodes a homolog of sulfhydrylases/cysteine synthases; CYSL-1 functions in neurons to transduce signals from H2S (hydrogen sulfide), which accumulates during hypoxia, to the EGL-9 proline hydroxylase to regulate O2-dependent behavioral plasticity in C. elegans via neuronal activation of the HIF-1 hypoxia-inducible transcription factor.; specifically, CYSL-1 physically interacts with EGL-9 in an H2S-dependent manner to sequester EGL-9 and relieve its inhibitory effect on HIF-1; a CYSL-1::GFP reporter fusion is expressed in the AVM sensory neuron, the BDU interneurons, and the pharyngeal I1 interneurons and M2 motor neurons, as well as in body wall muscles, hypodermis, and intestine; in vitro enzymatic assays and bioinformatics analyses suggest that CYSL-1 does not function as a cysteine synthase in vivo, but instead functions as a signaling molecule to transduce information about the environmental O2 level. | Paper_evidence | WBPaper00040881 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Apr 2012 00:00:00 | ||||||||
| Automated_description | Enables cysteine synthase activity and enzyme binding activity. Involved in cysteine biosynthetic process from serine and response to hypoxia. Located in striated muscle dense body. Expressed in body wall musculature; head ganglion; hypodermis; neurons; and non-striated muscle. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C17G1.7 | |||||||
| Corresponding_CDS_history | C17G1.7:wp151 | ||||||||
| Corresponding_transcript | C17G1.7.1 | ||||||||
| Other_sequence (61) | |||||||||
| Associated_feature | WBsf654291 | ||||||||
| WBsf654292 | |||||||||
| WBsf655698 | |||||||||
| WBsf655699 | |||||||||
| WBsf670911 | |||||||||
| WBsf718683 | |||||||||
| WBsf237815 | |||||||||
| WBsf237816 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00010927 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00109809 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109715 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033413 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040834 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109668 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081132 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109762 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram585 | ||||||||
| Expr9375 | |||||||||
| Expr9999 | |||||||||
| Expr15037 | |||||||||
| Expr1020846 | |||||||||
| Expr1033309 | |||||||||
| Expr1144877 | |||||||||
| Expr2010748 | |||||||||
| Expr2028984 | |||||||||
| Drives_construct | WBCnstr00002745 | ||||||||
| WBCnstr00014466 | |||||||||
| WBCnstr00014618 | |||||||||
| WBCnstr00033578 | |||||||||
| Construct_product | WBCnstr00013940 | ||||||||
| WBCnstr00014618 | |||||||||
| WBCnstr00033578 | |||||||||
| Antibody | WBAntibody00002331 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (234) | |||||||||
| Interaction (20) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| Map_info | Map | X | Position | 1.73138 | |||||
| Positive | Positive_clone | C17G1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
